Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, National and Kapodistrian University of Athens, Athens, Greece.
, Chalandri, Greece.
Eur J Pediatr. 2018 May;177(5):625-632. doi: 10.1007/s00431-018-3114-1. Epub 2018 Feb 23.
There is growing evidence that presepsin is a promising biomarker in the diagnosis of sepsis in adults. The objective of our study is to investigate current evidence related to the diagnostic accuracy of presepsin in neonatal sepsis. To accomplish this, we searched the Medline (1966-2017), Scopus (2004-2017), Clinicaltrials.gov (2008-2017), EMBASE (1980-2017), Cochrane Central Register of Controlled Trials CENTRAL (1999-2017), and Google Scholar (2004-2017) databases. Eleven studies were included in the present meta-analysis, with a total number of 783 neonates. The pooled sensitivity of serum presepsin for the prediction of neonatal sepsis was 0.91 (95% CI [0.87-0.93]) and the pooled specificity was 0.91 (95% CI [0.88-0.94]). The diagnostic odds ratio was 170.28 (95% CI [51.13-567.11]) and the area under the curve (AUC) was 0.9751 (SE 0.0117). Head-to-head comparison with AUC values of C-reactive protein (0.9748 vs. 0.8580) and procalcitonin (0.9596 vs. 0.7831) revealed that presepsin was more sensitive in detecting neonatal sepsis.
Current evidence support the use of presepsin in the early neonatal period in high-risk populations as its diagnostic accuracy seems to be high in detecting neonatal sepsis. What is known: • Neonatal sepsis is a leading cause of morbidity and mortality. • Current laboratory tests cannot accurately discriminate endangered neonates. What is new: • The diagnostic odds ratio of presepsin is 170.28 and the area under the curve is 0.9751. • According to our meta-analysis, presepsin is a useful protein that may help clinicians identify neonates at risk.
探讨降钙素原（PCT）和 C 反应蛋白（CRP）检测在儿童社区获得性肺炎（CAP）中的临床应用价值。方法：选择 2019 年 6 月至 2021 年 6 月我院收治的 128 例 CAP 患儿为观察组，同时选取同期在我院体检的 100 例健康儿童为对照组。比较两组 PCT、CRP 水平，绘制受试者工作特征（ROC）曲线，分析 PCT、CRP 单独及联合检测对 CAP 的诊断价值。结果：观察组 PCT、CRP 水平均高于对照组（P＜0.05）；ROC 曲线分析显示，PCT、CRP 单独及联合检测诊断 CAP 的曲线下面积（AUC）分别为 0.822、0.837、0.900，联合检测的 AUC 高于 PCT、CRP 单独检测（P＜0.05）。结论：PCT、CRP 联合检测可提高对儿童 CAP 的诊断效能，有助于临床早期诊断和治疗。
