Esen Selin Akturk, Karabulut Yusuf, Esen Irfan, Atmis Volkan
Department of Internal Medicine, Health Sciences University Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey.
Department of Rheumatology, Bursa Private Doruk Medical Center, Bursa, Turkey.
Curr Rheumatol Rev. 2018;14(3):271-278. doi: 10.2174/1573397113666170728123518.
Various psychiatric disorders, especially depression and anxiety, are seen in 2/3 of the chronic rheumatic diseases with chronic pain. In this study, we aimed to define anxiety and depression rates in Rheumatoid Arthritis (RA) and Ankylosing Spondylitis (AS) patients (under treatment) with similar age and gender; to compare the obtained data with each other and healthy control group; and also we aimed to investigate the relationship between human leukocyte antigen B27(HLA-B27) in AS, Rheumatoid Factor (RF) and anti-cyclic citrullinated peptide antibodies (anti-CCP) in RA with anxiety and depression.
46 patients with RA, 43 patients with AS and 29 healthy volunteers were evaluated with Beck Depression Inventory (BAI) and Beck Anxiety Inventory (BAI). Participants were also noted for their educational status, occupation status, family history of illness, duration of the disease and their current treatments. Then we compared the obtained data with the healthy control group. SPSS (IBM Corp. Released 2012. IBM SPSS Statistics for Windows, Version 21.p=0. Armonk, NY: IBM Corp.) was used for performing statistical analysis.
There was no difference between the groups according to age, sex, duration of illness (p=0.104, p=0.767, p=0.377). A significant difference between groups in terms of BAI values were determined (p=0.018). In subgroup analyzes, the median BAI value of AS group was found to be higher than the control group (p=0.020). There were no differences in BAI values between AS and RA groups or between RA and the control groups (p>0.05, p>0.05 respectively). Also, there were no differences between the groups in terms of BDI values (p=0.055).
Especially, chronic pain-related diseases are often associated with mental disorders, especially depression and anxiety. As a result, a multidisciplinary approach including psychiatric support should be used when planning treatment for these patients.
在三分之二伴有慢性疼痛的慢性风湿性疾病中可见各种精神障碍，尤其是抑郁症和焦虑症。在本研究中，我们旨在确定年龄和性别相似的类风湿关节炎（RA）和强直性脊柱炎（AS）患者（正在接受治疗）的焦虑和抑郁发生率；将获得的数据相互比较以及与健康对照组进行比较；此外，我们旨在研究AS中的人类白细胞抗原B27（HLA - B27）、RA中的类风湿因子（RF）和抗环瓜氨酸肽抗体（抗CCP）与焦虑和抑郁之间的关系。
使用贝克抑郁量表（BAI）和贝克焦虑量表（BAI）对46例RA患者、43例AS患者和29名健康志愿者进行评估。还记录了参与者的教育程度、职业状况、家族病史、疾病持续时间及其当前治疗情况。然后我们将获得的数据与健康对照组进行比较。使用SPSS（IBM公司。2012年发布。适用于Windows的IBM SPSS Statistics，版本21。p = 0。纽约州阿蒙克：IBM公司）进行统计分析。
根据年龄、性别、疾病持续时间，各组之间无差异（p = 0.104，p = 0.767，p = 0.377）。确定各组之间在BAI值方面存在显著差异（p = 0.018）。在亚组分析中，发现AS组的BAI中位数高于对照组（p = 0.020）。AS组与RA组之间或RA组与对照组之间的BAI值无差异（分别为p>0.05，p > 0.05）。此外，各组之间在BDI值方面也无差异（p = 0.055）。
特别是，与慢性疼痛相关的疾病通常与精神障碍有关，尤其是抑郁症和焦虑症。因此，在为这些患者制定治疗计划时应采用包括精神科支持在内的多学科方法。
