Stonin 2 Overexpression is Correlated with Unfavorable Prognosis and Tumor Invasion in Epithelial Ovarian Cancer.

Stonin 2 (), which functions in adjusting endocytotic complexes, is probably involved in the monitoring of the internalization of dopamine D2 receptors which have an inhibitory action of dopamine on tumor progression. However, its clinical significance in tumor progression and prognosis remains unclear. We explored the association between and the clinicopathological characteristics of epithelial ovarian cancer (EOC). The levels in ovarian cancer and normal cell lines and tissues were detected by real-time PCR and Western blot analyses. protein expression was also detected by an immunohistochemical analysis. The clinical significance of expression in ovarian cancer was statistically analyzed. significantly increased in the ovarian cancer cell lines and tissues compared to the normal ones. In the 89 samples tested, expression was significantly correlated with intraperitoneal metastasis, intestinal metastasis, intraperitoneal recurrence, ascites containing tumor cells, and CA153 level. Moreover, patients with protein overexpression were more likely to exhibit platinum resistance and to have undergone neoadjuvant chemotherapy. Patients with high protein expression had a tendency to have a shorter overall survival and a poor prognosis. A multivariate analysis showed that was an independent prognostic predictor for EOC patients. In conclusion, plays an important role in the progression and prognosis of ovarian carcinoma, especially in platinum resistance, intraperitoneal metastasis, and recurrence. can be a novel antitumor drug target and biomarker which predicts an unfavorable prognosis for EOC patients.