寨卡病毒直接感染外周神经元并诱导细胞死亡。
Zika virus directly infects peripheral neurons and induces cell death.
作者信息
Oh Yohan, Zhang Feiran, Wang Yaqing, Lee Emily M, Choi In Young, Lim Hotae, Mirakhori Fahimeh, Li Ronghua, Huang Luoxiu, Xu Tianlei, Wu Hao, Li Cui, Qin Cheng-Feng, Wen Zhexing, Wu Qing-Feng, Tang Hengli, Xu Zhiheng, Jin Peng, Song Hongjun, Ming Guo-Li, Lee Gabsang
机构信息
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana, USA.
出版信息
Nat Neurosci. 2017 Sep;20(9):1209-1212. doi: 10.1038/nn.4612. Epub 2017 Jul 31.
Zika virus (ZIKV) infection is associated with neurological disorders of both the CNS and peripheral nervous systems (PNS), yet few studies have directly examined PNS infection. Here we show that intraperitoneally or intraventricularly injected ZIKV in the mouse can infect and impact peripheral neurons in vivo. Moreover, ZIKV productively infects stem-cell-derived human neural crest cells and peripheral neurons in vitro, leading to increased cell death, transcriptional dysregulation and cell-type-specific molecular pathology.
寨卡病毒（ZIKV）感染与中枢神经系统（CNS）和外周神经系统（PNS）的神经紊乱有关，但很少有研究直接检测PNS感染情况。在此我们表明，在小鼠体内腹腔或脑室内注射ZIKV可在体内感染并影响外周神经元。此外，ZIKV在体外可有效感染干细胞衍生的人类神经嵴细胞和外周神经元，导致细胞死亡增加、转录失调以及细胞类型特异性分子病理学变化。
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