下调的长链非编码RNA SNHG1抑制结直肠癌的肿瘤发生。
Down-regulated long non-coding RNA SNHG1 inhibits tumor genesis of colorectal carcinoma.
作者信息
Sun Xiantao, Wang Zhimin, Yuan Weitang
机构信息
Department of Colorectal Surgery, The First Affiliated Hospital and Institute of Clinical Medicine, Zhengzhou University, Zhengzhou 450052, Henan, China.
Department of Endocrinology, The First Affiliated Hospital and Institute of Clinical Medicine, Zhengzhou University, Zhengzhou 450052, Henan, China.
出版信息
Cancer Biomark. 2017 Jul 19;20(1):67-73. doi: 10.3233/CBM-170112.
BACKGROUND
Colorectal carcinoma (CRC) is the vital cancer mortality worldwide and the long noncoding RNAs (lncRNAs) is considered as an important biomarker. The aim of this study was to examine the influence of lncRNA-SNHG1in CRC, and explore the relationship of lncRNA-SNHG1 and CRC, and consequently find a new therapeutic target for CRC patients.
METHODS
This study used 80 CRC patients and several cancer cell lines, with RNA interference technology to find the function of SNHG1.
RESULTS
SNHG1 expression was higher in CRC tissue lines other than the cancer adjacent tissues. Moreover, down-regulated SNHG1 resulting in smaller tumor size and lighter tumor weight. Additionally, down-regulated SNHG1 inhibited cell migration, proliferation and colony formation, but promoted cell apoptosis.
CONCLUSION
Our findings revealed that down-regulated SNHG1 could inhibit CRC tumor genesis and SNHG1 might act as an important potential therapeutic target in CRC treatment.
背景
结直肠癌（CRC）是全球癌症死亡的主要原因，长链非编码RNA（lncRNAs）被认为是一种重要的生物标志物。本研究旨在探讨lncRNA-SNHG1对结直肠癌的影响，探索lncRNA-SNHG1与结直肠癌的关系，从而为结直肠癌患者找到新的治疗靶点。
方法
本研究使用80例结直肠癌患者和几种癌细胞系，采用RNA干扰技术来探究SNHG1的功能。
结果
SNHG1在结直肠癌组织系中的表达高于癌旁组织。此外，下调SNHG1可导致肿瘤体积减小和肿瘤重量减轻。此外，下调SNHG1可抑制细胞迁移、增殖和集落形成，但促进细胞凋亡。
结论
我们的研究结果表明，下调SNHG1可抑制结直肠癌肿瘤发生，SNHG1可能是结直肠癌治疗中一个重要的潜在治疗靶点。
Zotero 插件