Karakaplan Mustafa, Gülabi Deniz, Topgül Haldun, Elmalı Nurzat
Department of Orthopedics and Traumatology, Medical Faculty of İnönü University, 44280 Malatya, Turkey.
Eklem Hastalik Cerrahisi. 2017 Aug;28(2):107-13. doi: 10.5606/ehc.2017.54402.
This study aims to investigate the effect of platelet-rich plasma (PRP) on femoral head osteonecrosis and compare it with bone marrow injection and core decompression.
A total of 30 healthy, adult, male New Zealand white rabbits (mean weight 2.25±0.15 kg; range 2.0 to 2.5 kg) were used in the study. To create experimental osteonecrosis in all rabbits, 40 mg/kg methylprednisolone acetate was applied intramuscularly. Rabbits were randomly allocated into three groups with 10 rabbits in each: drilling group, PRP group, and bone marrow group. The non-drilled hips of the drilling group were identified as the control group.
Rate of necrotic bone was lower in the PRP group compared to other groups. Highest rate of necrotic bone was detected in the control group. New bone formation rate was higher in the PRP group compared to other groups. Lowest new bone formation rate was determined in the control group. Inflammatory reaction rate was higher in the PRP group compared to other groups.
Platelet-rich plasma injection may play a positive role in the treatment of steroid-associated osteonecrosis in a rabbit model.
本研究旨在探讨富血小板血浆（PRP）对股骨头坏死的影响，并将其与骨髓注射和髓芯减压进行比较。
本研究共使用30只健康成年雄性新西兰白兔（平均体重2.25±0.15千克；范围2.0至2.5千克）。为使所有兔子产生实验性骨坏死，肌肉注射40毫克/千克醋酸甲基泼尼松龙。兔子被随机分为三组，每组10只：钻孔组、PRP组和骨髓组。钻孔组未钻孔的髋关节被确定为对照组。
与其他组相比，PRP组坏死骨率更低。对照组坏死骨率最高。与其他组相比，PRP组新骨形成率更高。对照组新骨形成率最低。与其他组相比，PRP组炎症反应率更高。
在兔模型中，富血小板血浆注射可能在类固醇相关骨坏死的治疗中发挥积极作用。
