巴西与病毒性肝炎相关的年龄标准化死亡率。

Age-standardized mortality rates related to viral hepatitis in Brazil.

作者信息

Perazzo Hugo, Pacheco Antonio G, Luz Paula M, Castro Rodolfo, Hyde Chris, Fittipaldi Juliana, Rigolon Caroline, Cardoso Sandra W, Grinsztejn Beatriz, Veloso Valdiléa G

机构信息

Fundação Oswaldo Cruz (FIOCRUZ), Instituto Nacional de Infectologia Evandro Chagas (INI), Laboratório de Pesquisa Clínica em DST e AIDS (LAPCLIN-AIDS), Rio de Janeiro, Brazil.

Fundação Oswaldo Cruz (FIOCRUZ), Programa de Computação Científica (PROCC), Rio de Janeiro, Brazil.

出版信息

BMC Infect Dis. 2017 Jul 31;17(1):527. doi: 10.1186/s12879-017-2619-y.

DOI:10.1186/s12879-017-2619-y

PMID:28760138

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5537933/

Abstract

BACKGROUND

Liver-related mortality has been increasing worldwide. We aimed to estimate the age-standardized mortality rates from viral hepatitis in Brazil.

METHODS

The Brazilian National Death Registry was analyzed from 2008 to 2014. Viral hepatitis deaths were defined by the following ICD-10 codes in the death certificate: hepatitis A [B15.0; B15.9]; hepatitis B [B16.2; B16.9; B18.1]; hepatitis C [B17.1; B18.2]; hepatitis Delta [B16.0; B16.1; B18.0; B17.0] and other viral hepatitis [B17.2; B17.8; B18.8; B18.9; B19.0; B19.9]. Crude mortality rates were calculated by the ratio between total number of deaths and estimated population. Mortality rates were age-standardized by the direct method using the WHO standard population.

RESULTS

Thirty four thousand ,nine hundred seventy eight deaths had viral hepatitis mentioned in their death certificate [65% male, aged 58 years, 73% associated with hepatitis C]. Age-standardized mortality rate (95% CI) due to viral hepatitis was 2.695 (2.667-2.724) deaths per 100,000 inhabitants: South region had the higher rates [3.997 (3.911-4.085)]. Mortality rates associated with hepatitis A and Delta were 0.032 (0.029-0.035) and 0.028 (0.025-0.031), respectively. Hepatitis C mortality rates were 4-fold higher than those associated with hepatitis B [1.964 (1.940-1.989) vs 0.500 (0.488-0.512)]. South region had the higher rates for hepatitis C [3.163 (3.087-3.241)] and North had the higher rates for hepatitis A [0.066 (0.049-0.087)], B [0.986 (0.918-1.058)] and Delta [0.220 (0.190-0.253)].

CONCLUSION

Viral hepatitis remains a major public health issue in Brazil. Mortality rates were not homogeneous across the country, suggesting that health policies should be customized according to geographical location.

摘要

背景

全球范围内，肝脏相关死亡率一直在上升。我们旨在估算巴西病毒性肝炎的年龄标准化死亡率。

方法

对2008年至2014年巴西国家死亡登记处的数据进行分析。病毒性肝炎死亡由死亡证明中的以下国际疾病分类第十版（ICD - 10）编码定义：甲型肝炎[B15.0；B15.9]；乙型肝炎[B16.2；B16.9；B18.1]；丙型肝炎[B17.1；B18.2]；丁型肝炎[B16.0；B16.1；B18.0；B17.0]以及其他病毒性肝炎[B17.2；B17.8；B18.8；B18.9；B19.0；B19.9]。粗死亡率通过死亡总数与估计人口数的比率计算得出。死亡率采用直接法，以世界卫生组织标准人口进行年龄标准化。

结果

在其死亡证明中提及病毒性肝炎的死亡人数为34978例[男性占65%，年龄58岁，73%与丙型肝炎相关]。病毒性肝炎的年龄标准化死亡率（95%置信区间）为每10万居民2.695（2.667 - 2.724）例死亡：南部地区的死亡率较高[3.997（3.911 - 4.085）]。与甲型肝炎和丁型肝炎相关的死亡率分别为0.032（0.029 - 0.035）和0.028（0.025 - 0.031）。丙型肝炎的死亡率比乙型肝炎高4倍[1.964（1.940 - 1.989）对0.500（0.488 - 0.512）]。南部地区丙型肝炎的死亡率较高[3.163（3.087 - 3.241）]，北部地区甲型肝炎[0.066（0.049 - 0.087）]、乙型肝炎[0.986（0.918 - 1.058）]和丁型肝炎[0.220（0.190 - 0.253）]的死亡率较高。