青少年慢性疲劳综合征/肌痛性脑脊髓炎（CFS/ME）的睡眠质量。
Sleep Quality in Adolescents With Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).
机构信息
Clinical Sciences, Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia.
Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia.
出版信息
J Clin Sleep Med. 2017 Sep 15;13(9):1057-1066. doi: 10.5664/jcsm.6722.
STUDY OBJECTIVES
Little is known about the type and severity of sleep disturbances in the pediatric chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) population, compared with healthy adolescents. Using a range of objective and subjective measures, the aim of this study was to investigate sleep quality, the relationship between objective and subjective measures of sleep quality, and their associations with anxiety in adolescents with CFS/ME compared with healthy controls.
METHODS
Twenty-one adolescents with CFS/ME aged 13 to 18 years (mean age 15.57 ± 1.40), and 145 healthy adolescents aged 13 to 18 years (mean age 16.2 ± 1.00) wore actigraphy watches continuously for 2 weeks to collect a number of objective sleep variables. The Pittsburgh Sleep Quality Index was used to obtain a subjective measure of sleep quality. Anxiety was measured by the Spence Children's Anxiety scale.
RESULTS
On average over the 2-week period, adolescents with CFS/ME were found to have (1) significantly longer objective sleep onset latency, time in bed, total sleep time, and a later rise time (all < .005), and (2) significantly poorer subjective sleep quality ( < .001), compared with healthy adolescents. The CFS/ME patient group displayed higher levels of anxiety ( < .05), and in both groups, higher levels of anxiety were significantly related to poorer subjective sleep quality ( < .001).
CONCLUSIONS
This study provides objective and subjective evidence of sleep disturbance in adolescents with CFS/ME compared with healthy adolescent controls.
研究目的
与健康青少年相比，小儿慢性疲劳综合征/肌痛性脑脊髓炎（CFS/ME）患者的睡眠障碍类型和严重程度知之甚少。本研究旨在使用一系列客观和主观测量方法，调查 CFS/ME 青少年的睡眠质量、客观和主观睡眠质量测量之间的关系，以及它们与焦虑之间的关系，与健康对照组相比。
方法
21 名年龄在 13 至 18 岁（平均年龄 15.57 ± 1.40）的 CFS/ME 青少年和 145 名年龄在 13 至 18 岁的健康青少年（平均年龄 16.2 ± 1.00）连续佩戴活动记录仪 2 周，以收集多项客观睡眠变量。匹兹堡睡眠质量指数用于获得主观睡眠质量的测量值。焦虑采用斯宾塞儿童焦虑量表进行测量。
结果
在 2 周的平均时间内，与健康青少年相比，CFS/ME 青少年发现（1）客观入睡潜伏期、卧床时间、总睡眠时间和起床时间明显延长（均<0.005），以及（2）主观睡眠质量明显较差（<0.001）。CFS/ME 患者组表现出更高水平的焦虑（<0.05），在两组中，更高水平的焦虑与主观睡眠质量较差显著相关（<0.001）。
结论
与健康青少年对照组相比，本研究为 CFS/ME 青少年提供了客观和主观的睡眠障碍证据。
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