Southam Hannah M, Butler Jonathan A, Chapman Jonathan A, Poole Robert K
The University of Sheffield, Sheffield, United Kingdom.
The University of Sheffield, Sheffield, United Kingdom.
Adv Microb Physiol. 2017;71:1-96. doi: 10.1016/bs.ampbs.2017.03.001. Epub 2017 May 29.
Ruthenium is seldom mentioned in microbiology texts, due to the fact that this metal has no known, essential roles in biological systems, nor is it generally considered toxic. Since the fortuitous discovery of cisplatin, first as an antimicrobial agent and then later employed widely as an anticancer agent, complexes of other platinum group metals, such as ruthenium, have attracted interest for their medicinal properties. Here, we review at length how ruthenium complexes have been investigated as potential antimicrobial, antiparasitic and chemotherapeutic agents, in addition to their long and well-established roles as biological stains and inhibitors of calcium channels. Ruthenium complexes are also employed in a surprising number of biotechnological roles. It is in the employment of ruthenium complexes as antimicrobial agents and alternatives or adjuvants to more traditional antibiotics, that we expect to see the most striking developments in the future. Such novel contributions from organometallic chemistry are undoubtedly sorely needed to address the antimicrobial resistance crisis and the slow appearance on the market of new antibiotics.
钌在微生物学教科书中很少被提及，因为这种金属在生物系统中没有已知的必需作用，也通常不被认为具有毒性。自从顺铂被偶然发现，先是作为一种抗菌剂，后来又被广泛用作抗癌剂以来，其他铂族金属的配合物，如钌，因其药用特性而引起了人们的兴趣。在这里，我们详细回顾了钌配合物作为潜在的抗菌、抗寄生虫和化疗药物是如何被研究的，此外还回顾了它们作为生物染色剂和钙通道抑制剂的长期且已确立的作用。钌配合物还被用于数量惊人的生物技术领域。我们预计，在将钌配合物用作抗菌剂以及作为更传统抗生素的替代品或佐剂方面，未来将会有最显著的发展。有机金属化学的这些新贡献无疑是应对抗菌药物耐药性危机以及新抗生素上市缓慢问题所急需的。
