基因工程细菌治疗人类疾病。

Genetically Engineered Bacteria for Treating Human Disease.

机构信息

Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.

出版信息

Trends Pharmacol Sci. 2017 Sep;38(9):763-764. doi: 10.1016/j.tips.2017.07.001. Epub 2017 Jul 28.

DOI:10.1016/j.tips.2017.07.001

Abstract

Bacteria have now been harnessed to combat human diseases, especially to meet the challenge of antimicrobial resistance. Modulating the microbiome, particularly by genetically engineering the bacteria, has provided proof-of-concept as potential pharmacotherapy, but those involved in this field should engage in discussion as how to move forward.

摘要

细菌现已被用于对抗人类疾病，尤其是用于应对抗微生物药物耐药性挑战。通过调节微生物组，特别是通过对细菌进行基因工程改造，为潜在的药物治疗提供了概念验证，但该领域的相关人员应该参与讨论如何推进这一领域。