Bateman D E, McDermott J R, Perry R H, Dimaline R, Biggins J A, Edwardson J A
J Neurol Neurosurg Psychiatry. 1986 Sep;49(9):1074-6. doi: 10.1136/jnnp.49.9.1074.
Forty nine gliomas were analysed for the following neuropeptides: somatostatin (SS), substance P (SP), neurotensin (NT) and vasoactive intestinal polypeptide (VIP) and the pituitary peptide, adrenocorticotrophin (ACTH). A significant amount of authentic SS was found in a medulloblastoma, and low concentrations of SP and NT immunoreactivity in an ependymoma and cerebellar astrocytoma respectively. The majority of the other gliomas did not contain detectable levels of these five neuropeptides. Low levels of neuropeptides were found in some specimens probably due to contamination with cerebral cortex.
对49例神经胶质瘤进行了以下神经肽分析:生长抑素(SS)、P物质(SP)、神经降压素(NT)、血管活性肠肽(VIP)以及垂体肽促肾上腺皮质激素(ACTH)。在1例髓母细胞瘤中发现了大量的真性SS,在1例室管膜瘤和1例小脑星形细胞瘤中分别发现了低浓度的SP和NT免疫反应性。其他大多数神经胶质瘤未检测到这5种神经肽。在一些标本中发现了低水平的神经肽,可能是由于被大脑皮质污染所致。