Capasso F, Mascolo N, Autore G, Romano V
J Pharm Pharmacol. 1986 Aug;38(8):627-9. doi: 10.1111/j.2042-7158.1986.tb03097.x.
The effects of some laxatives were examined on the formation of histamine, 5-hydroxytryptamine (5-HT) and prostaglandin-like material (PG-LM) by rat intestine in-vitro. Castor oil, senna, sulphosuccinate and bisacodyl, but not mannitol or lactulose, in doses that cause laxation, increased the formation of histamine, 5-HT and PG-LM. Indomethacin or hydrocortisone reduced the increase of PG-LM formation. The data support the idea that the laxative effects of these intestinal secretagogues are due to increased intestinal production of PG-LM, histamine and 5-HT.
研究了某些泻药对大鼠离体肠组织中组胺、5-羟色胺（5-HT）和前列腺素样物质（PG-LM）生成的影响。蓖麻油、番泻叶、磺基琥珀酸酯和比沙可啶，而非甘露醇或乳果糖，在引起腹泻的剂量下，会增加组胺、5-HT和PG-LM的生成。吲哚美辛或氢化可的松可减少PG-LM生成的增加。这些数据支持了这样一种观点，即这些肠道促分泌剂的泻药作用是由于肠道中PG-LM、组胺和5-HT生成增加所致。
