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酚酞可刺激大鼠空肠、回肠和结肠生成组胺、5-羟色胺以及类前列腺素物质。

Phenolphthalein stimulates the formation of histamine, 5-hydroxytryptamine and prostaglandin-like material by rat jejunum, ileum and colon.

作者信息

Autore G, Capasso F, Mascolo N

出版信息

Br J Pharmacol. 1984 Feb;81(2):347-9. doi: 10.1111/j.1476-5381.1984.tb10085.x.

DOI:10.1111/j.1476-5381.1984.tb10085.x
PMID:6704594
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1986896/
Abstract

The effects of phenolphthalein on the formation of histamine, 5-hydroxytryptamine(5-HT) and prostaglandin-like material by rat intestine were examined in vivo. Phenolphthalein, in a dose that causes laxation increased the formation of histamine, 5-HT and prostaglandin-like material, and indomethacin reduced these increases. The data support the idea that the laxative effect of phenolphthalein is due to increased intestinal production of prostaglandin, histamine and 5-HT.

摘要

在体内研究了酚酞对大鼠肠道组胺、5-羟色胺（5-HT）和前列腺素样物质形成的影响。能引起腹泻的剂量的酚酞增加了组胺、5-HT和前列腺素样物质的形成，而吲哚美辛可降低这些增加。这些数据支持这样一种观点，即酚酞的致泻作用是由于肠道前列腺素、组胺和5-HT生成增加所致。

相似文献

1
Phenolphthalein stimulates the formation of histamine, 5-hydroxytryptamine and prostaglandin-like material by rat jejunum, ileum and colon.酚酞可刺激大鼠空肠、回肠和结肠生成组胺、5-羟色胺以及类前列腺素物质。
Br J Pharmacol. 1984 Feb;81(2):347-9. doi: 10.1111/j.1476-5381.1984.tb10085.x.
2
Laxatives and the production of autacoids by rat colon.泻药与大鼠结肠自分泌物质的产生
J Pharm Pharmacol. 1986 Aug;38(8):627-9. doi: 10.1111/j.2042-7158.1986.tb03097.x.
3
The effect of cathartics on prostaglandin synthesis by rat gastro-intestinal tract.
Prostaglandins Leukot Med. 1982 Apr;8(4):389-97. doi: 10.1016/0262-1746(82)90062-2.
4
The production of arachidonate lipoxygenase products by rat intestine is increased by phenolphthalein.酚酞可增加大鼠肠道花生四烯酸脂氧合酶产物的生成。
Eur J Pharmacol. 1984 Nov 13;106(2):419-22. doi: 10.1016/0014-2999(84)90732-5.
5
Effect of phenolphthalein on monkey intestinal water and electrolyte transport.
Am J Physiol. 1982 Oct;243(4):G268-75. doi: 10.1152/ajpgi.1982.243.4.G268.
6
Potentiation by phenolphthalein of the responses of guinea-pig ileum and rat stomach strip to PGE2 and other agonists.酚酞对豚鼠回肠和大鼠胃条对前列腺素E2及其他激动剂反应的增强作用。
Eur J Pharmacol. 1988 Jan 5;145(1):1-5. doi: 10.1016/0014-2999(88)90341-x.
7
Comparison of phenolphthalein and phenolphthalein glucuronide on net water transport in rat ileum and colon.
Dig Dis Sci. 1983 Sep;28(9):827-32. doi: 10.1007/BF01296906.
8
Neural involvement in 5-hydroxytryptamine-induced net electrogenic ion secretion in the rat intestine in-vivo.
J Pharm Pharmacol. 1996 Apr;48(4):411-6. doi: 10.1111/j.2042-7158.1996.tb05943.x.
9
Is the effect of diphenolic laxatives mediated via release of prostaglandin E?
Experientia. 1978 Mar 15;34(3):386-7. doi: 10.1007/BF01923051.
10
Role of local prostaglandin synthesis in the modulation of proliferative activity of rat colonic epithelium.局部前列腺素合成在调节大鼠结肠上皮细胞增殖活性中的作用。
J Clin Invest. 1983 Oct;72(4):1365-75. doi: 10.1172/JCI111093.

本文引用的文献

1
The effect of cathartics on prostaglandin synthesis by rat gastro-intestinal tract.
Prostaglandins Leukot Med. 1982 Apr;8(4):389-97. doi: 10.1016/0262-1746(82)90062-2.
2
Influence of prostacyclin and indomethacin on castor oil-induced gastrointestinal effects in rats.前列环素和吲哚美辛对蓖麻油诱导的大鼠胃肠道效应的影响。
J Pharm Pharmacol. 1983 Mar;35(3):152-6. doi: 10.1111/j.2042-7158.1983.tb04295.x.
3
The effect of prostaglandins on gastrointestinal serotonin in the rat.前列腺素对大鼠胃肠道血清素的影响。
Eur J Pharmacol. 1968 Sep;4(2):224-7. doi: 10.1016/0014-2999(68)90181-7.
4
Release of prostaglandin E-1 from the rat stomach.前列腺素E-1从大鼠胃中的释放。
Nature. 1967 Dec 2;216(5118):873-6. doi: 10.1038/216873a0.
5
Effect of indomethacin on endotoxin-induced production of prostaglandins in the isolated rabbit jejunum.吲哚美辛对脂多糖诱导的离体兔空肠中前列腺素生成的影响。
Adv Prostaglandin Thromboxane Res. 1976;2:557-60.
6
Effect of ricinoleic acid and other laxatives on net water flux and prostaglandin E release by the rat colon.
J Pharm Pharmacol. 1979 Oct;31(10):681-5. doi: 10.1111/j.2042-7158.1979.tb13628.x.
7
Evidence against the release of prostaglandin-like material from isolated intestinal tissue by pure cholera toxin.关于纯霍乱毒素不会从离体肠组织释放出类前列腺素物质的证据。
Prostaglandins. 1977 Mar;13(3):431-6. doi: 10.1016/0090-6980(77)90023-5.