酚酞可刺激大鼠空肠、回肠和结肠生成组胺、5-羟色胺以及类前列腺素物质。
Phenolphthalein stimulates the formation of histamine, 5-hydroxytryptamine and prostaglandin-like material by rat jejunum, ileum and colon.
作者信息
Autore G, Capasso F, Mascolo N
出版信息
Br J Pharmacol. 1984 Feb;81(2):347-9. doi: 10.1111/j.1476-5381.1984.tb10085.x.
Abstract
The effects of phenolphthalein on the formation of histamine, 5-hydroxytryptamine(5-HT) and prostaglandin-like material by rat intestine were examined in vivo. Phenolphthalein, in a dose that causes laxation increased the formation of histamine, 5-HT and prostaglandin-like material, and indomethacin reduced these increases. The data support the idea that the laxative effect of phenolphthalein is due to increased intestinal production of prostaglandin, histamine and 5-HT.
摘要
在体内研究了酚酞对大鼠肠道组胺、5-羟色胺（5-HT）和前列腺素样物质形成的影响。能引起腹泻的剂量的酚酞增加了组胺、5-HT和前列腺素样物质的形成，而吲哚美辛可降低这些增加。这些数据支持这样一种观点，即酚酞的致泻作用是由于肠道前列腺素、组胺和5-HT生成增加所致。
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Phenolphthalein stimulates the formation of histamine, 5-hydroxytryptamine and prostaglandin-like material by rat jejunum, ileum and colon.酚酞可刺激大鼠空肠、回肠和结肠生成组胺、5-羟色胺以及类前列腺素物质。
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