TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.
TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA
Antimicrob Agents Chemother. 2017 Sep 22;61(10). doi: 10.1128/AAC.01296-17. Print 2017 Oct.
Oxazolidinones are promising candidates for the treatment of infections. We isolated linezolid-resistant strains from H37Rv (Euro-American) and HN878 (East-Asian) strains; resistance frequencies were similar in the two strains. Mutations were identified in ribosomal protein L3 (RplC) and the 23S rRNA (). All mutant strains were cross resistant to sutezolid; a subset was cross resistant to chloramphenicol. Mutations in led to growth impairment and decreased fitness that may limit spread in clinical settings.
恶唑烷酮类是治疗感染的有前途的候选药物。我们从 H37Rv（欧美）和 HN878（东亚）株中分离出线唑烷酮耐药株；两种菌株的耐药频率相似。核糖体蛋白 L3（RplC）和 23S rRNA（）中鉴定出突变。所有突变株对苏替唑均交叉耐药；一部分对氯霉素交叉耐药。突变导致生长受损和适应性降低，这可能限制其在临床环境中的传播。
