结核分枝杆菌对利奈唑胺和地拉曼尼的耐药性：来自刚果民主共和国布卡武的一例报告。
Drug resistance of Mycobacterium tuberculosis to linezolid and delamanid: a case report from Bukavu, Democratic Republic of Congo.
作者信息
Bisimwa Bertin C, Bahizire Esto, Kiselinova Maja, Byela Valéry, Ngabonziza Jean Claude S, Hakizayezu François, Runyambo Docteur, Meehan Conor J, Mulders Wim, Cuella-Martin Isabel, Rigouts Leen, Birembano Freddy, Callens Steven, de Jong Bouke C, Kaswa Michel
机构信息
Center for Tropical Diseases & Global Health, Université Catholique de Bukavu, Bukavu, South Kivu, Congo.
Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
出版信息
BMC Infect Dis. 2025 Jul 12;25(1):913. doi: 10.1186/s12879-025-11348-w.
Abstract
The emergence of resistance is of great concern in the control of TB, especially to the new and repurposed drugs needed for the treatment of rifampicin resistance. We report a patient from South Kivu in the Eastern Democratic Republic of the Congo with primary resistance to delamanid and linezolid without treatment experience with these drugs. The identification of novel resistance mutations raises concerns about the potential global spread and poor outcomes of the WHO-recommended oral treatment regimens, highlighting the need for the urgent rollout of DST.
摘要
耐药性的出现是结核病控制中极为令人担忧的问题，尤其是对治疗利福平耐药所需的新型和重新利用的药物而言。我们报告了一名来自刚果民主共和国东部南基伍省的患者，其对地拉马尼和利奈唑胺存在原发性耐药，且此前未使用过这些药物进行治疗。新型耐药突变的发现引发了对世界卫生组织推荐的口服治疗方案可能在全球传播以及治疗效果不佳的担忧，凸显了迫切需要推广开展药敏试验的必要性。
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本文引用的文献
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Lancet Microbe. 2020 Jun;1(2):e74-e83. doi: 10.1016/S2666-5247(20)30007-0. Epub 2020 Jun 8.
2
Thin-Layer-Agar-Based Direct Phenotypic Drug Susceptibility Testing on Sputum in Eswatini Rapidly Detects Mycobacterium tuberculosis Growth and Rifampicin Resistance Otherwise Missed by WHO-Endorsed Diagnostic Tests.基于薄层琼脂的斯威士兰痰直接药敏试验快速检测结核分枝杆菌生长和利福平耐药，而世界卫生组织推荐的诊断检测方法可能会漏检。
Antimicrob Agents Chemother. 2021 May 18;65(6). doi: 10.1128/AAC.02263-20.
3
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Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs.整合信息学工具和便携式测序技术，用于快速检测抗结核药物耐药性。
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