Elmas Bahri, Karacan Mehmet, Dervişoğlu Pınar, Kösecik Mustafa, İşgüven Şükriye Pınar, Bal Ceylan
Department of Pediatrics, Faculty of Medicine, Sakarya University; Sakarya-Turkey.
Anatol J Cardiol. 2017 Nov;18(5):361-369. doi: 10.14744/AnatolJCardiol.2017.7740. Epub 2017 Jul 25.
Childhood obesity is an important cause of cardiovascular risk with chronic inflammation. Oxidative stress may contribute to the pathogenesis of obesity-related cardiovascular pathologies. We aimed to evaluate thiol/disulphide homeostasis as a novel and sensitive marker of oxidative stress and to evaluate its relationship with some inflammatory and cardiovascular markers in obese children.
In this case-controlled study, 65 children with exogenous obesity and 64 healthy children, as a control group, were included. In both groups, thiol/disulphide homeostasis parameters and inflammatory (white blood cells, platelets, mean corpuscular volume, neutrophil/lymphocyte ratio, and high-sensitivity C-reactive protein) and cardiovascular (epicardial adipose tissue thickness and left ventricular mass index) markers were studied. Correlation analyses of thiol/disulphide homeostasis parameters with body mass index standard deviation scores (BMI SDS) and inflammatory and cardiovascular markers were performed. Receiver-operating characteristic analysis was performed to determine the sensitivity, specificity, and optimal cut-off values of thiol/disulphide homeostasis parameters.
Native thiol, total thiol, and native thiol/total thiol ratios (antioxidant parameters) were lower (p<0.05) and disulphide/native thiol and disulphide/total thiol ratios (oxidant parameters) were higher in the obese group than in the control group (p<0.01). A positive correlation of oxidant parameters with BMI SDS and inflammatory markers was found. However, a negative correlation of antioxidant parameters with BMI SDS and inflammatory markers was found. The specificities of disulphide/native thiol and disulphide/total thiol ratios were higher in the obese group.
The impairment in thiol/disulphide homeostasis, which is indicative of oxidative stress, is associated with inflammation in obesity. In addition, cardiovascular involvement may also contribute to this impairment.
儿童肥胖是伴有慢性炎症的心血管疾病风险的重要成因。氧化应激可能在肥胖相关心血管疾病的发病机制中发挥作用。我们旨在评估硫醇/二硫化物稳态作为氧化应激的一种新型敏感标志物，并评估其与肥胖儿童某些炎症和心血管标志物的关系。
在这项病例对照研究中，纳入了65名外源性肥胖儿童和64名健康儿童作为对照组。对两组儿童均研究了硫醇/二硫化物稳态参数以及炎症标志物（白细胞、血小板、平均红细胞体积、中性粒细胞/淋巴细胞比值和高敏C反应蛋白）和心血管标志物（心外膜脂肪组织厚度和左心室质量指数）。对硫醇/二硫化物稳态参数与体重指数标准差评分（BMI SDS）以及炎症和心血管标志物进行了相关性分析。进行了受试者操作特征分析，以确定硫醇/二硫化物稳态参数的敏感性、特异性和最佳临界值。
肥胖组的天然硫醇、总硫醇以及天然硫醇/总硫醇比值（抗氧化参数）较低（p<0.05），而二硫化物/天然硫醇和二硫化物/总硫醇比值（氧化参数）高于对照组（p<0.01）。发现氧化参数与BMI SDS和炎症标志物呈正相关。然而，抗氧化参数与BMI SDS和炎症标志物呈负相关。肥胖组中二硫化物/天然硫醇和二硫化物/总硫醇比值的特异性较高。
硫醇/二硫化物稳态受损表明存在氧化应激，这与肥胖中的炎症相关。此外，心血管受累也可能导致这种损害。
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