Numune Education and Research Hospital Cardiology Department, Ankara, Turkey.
Numune Education and Research Hospital Cardiology Department, Ankara, Turkey.
Atherosclerosis. 2016 Oct;253:209-213. doi: 10.1016/j.atherosclerosis.2016.07.904. Epub 2016 Jul 16.
Thiol/disulfide homeostasis has an important role in the antioxidant defense system. Oxidative stress may contribute to the pathogenesis of coronary artery ectasia. The aim of this study was to evaluate plasma thiol levels and thiol/disulfide homeostasis in patients with isolated coronary artery ectasia.
Forty-one patients with isolated coronary artery ectasia and 72 patients with normal coronary arteries were included in the study. Markis classification and number of ectatic coronary arteries were recorded. Plasma total thiol levels, native thiol levels and disulfide levels were measured. Thiol/disulfide homeostasis was appraised by calculating thiol/disulfide ratio.
Plasma native thiol levels were significantly lower (336.9 (252.9-374.1) vs. 353.1 (327.0-380.0), p = 0.041) and disulfide levels were significantly higher (18.9 ± 6.3 vs. 16.6 ± 3.4, p = 0.014) in patients with coronary artery ectasia than control patients. Both native thiol/disulfide and total thiol/disulfide ratio was significantly lower in the coronary artery ectasia group (p < 0.001). Multivariate logistic regression analysis revealed that native thiol levels, disulfide levels and native thiol/disulfide ratio were independently associated with the presence of coronary artery ectasia. Thiol/disulfide ratio was not different according to number of ectatic coronary arteries and there was no association between thiol/disulfide ratio and Markis classification.
Plasma thiol/disulfide homeostasis is altered in patients with coronary artery ectasia.
巯基/二硫键平衡在抗氧化防御系统中具有重要作用。氧化应激可能导致冠状动脉扩张症的发病机制。本研究旨在评估孤立性冠状动脉扩张症患者的血浆巯基水平和巯基/二硫键平衡。
本研究纳入了 41 例孤立性冠状动脉扩张症患者和 72 例冠状动脉正常患者。记录 Markis 分类和扩张冠状动脉的数量。测量血浆总巯基水平、天然巯基水平和二硫键水平。通过计算巯基/二硫键比值来评估巯基/二硫键平衡。
与对照组相比，冠状动脉扩张症患者的血浆天然巯基水平显著降低（336.9（252.9-374.1）比 353.1（327.0-380.0），p=0.041），二硫键水平显著升高（18.9±6.3 比 16.6±3.4，p=0.014）。冠状动脉扩张症组的天然巯基/二硫键和总巯基/二硫键比值均显著降低（p<0.001）。多变量逻辑回归分析显示，天然巯基水平、二硫键水平和天然巯基/二硫键比值与冠状动脉扩张症的存在独立相关。巯基/二硫键比值与扩张冠状动脉的数量无关，与 Markis 分类也无相关性。
冠状动脉扩张症患者的血浆巯基/二硫键平衡发生改变。
