Shah Dixit, Shah Sanket, Mahajan Amit, Shah Navin, Sanghvi Darshan, Shah Rishabh
Department of Oral and Maxillofacial Surgery, K. M. Shah Dental College and Hospital, Vadodara, Gujarat, India.
Natl J Maxillofac Surg. 2017 Jan-Jun;8(1):12-18. doi: 10.4103/njms.NJMS_4_17.
The surgical removal of impacted mandibular third molars is one of the most commonly performed dentoalveolar procedures in oral and maxillofacial surgery and is associated with varying degrees of postoperative discomfort. Pain, trismus, and swelling are the most common postoperative complaints, and these influence a patient's quality of life in the days after surgery.
A comparative study of the 32 patients, 16 were allocated to receive ketorolac and 16 patients were allocated to receive tapentadol. As the data for this study were collected at different time points, analysis for the longitudinal study was done. The main outcome variable, pain level was measured in five-ordered categories. As we had ordinal data in our study, we first checked for marginal homogeneity through Cochran-Mantel-Haenszel test.
In the present study, the results show that there is no statistically significant difference between the two treatment groups ( = 0.1184). According to results, there is no significant group by time interaction, which means both drugs have shown almost equal efficacy at different time points. Similarly, there is no difference in efficacy of the two drugs across gender level.
The present findings showed that there is no statistically significant difference between the two treatment groups, although ketorolac is more effective for immediate pain reduction than tapentadol. However, the overall reduction of pain using both groups has no significant difference.
下颌阻生第三磨牙的外科拔除是口腔颌面外科最常进行的牙槽外科手术之一，术后会伴有不同程度的不适。疼痛、张口受限和肿胀是最常见的术后症状，这些会影响患者术后几天的生活质量。
对32例患者进行了一项对比研究，16例患者被分配接受酮咯酸治疗，16例患者被分配接受曲马多治疗。由于本研究的数据是在不同时间点收集的，因此对纵向研究进行了分析。主要结局变量疼痛程度采用五级分类法进行测量。由于我们的研究中有有序数据，我们首先通过 Cochr an-Mantel-Haenszel检验检查边缘齐性。
在本研究中，结果表明两个治疗组之间没有统计学上的显著差异（ = 0.1184）。根据结果，没有显著的组与时间交互作用，这意味着两种药物在不同时间点显示出几乎相同的疗效。同样，两种药物在不同性别水平上的疗效也没有差异。
本研究结果表明，两个治疗组之间没有统计学上的显著差异，尽管酮咯酸在即刻减轻疼痛方面比曲马多更有效。然而，两组在疼痛总体减轻方面没有显著差异。
