Lv Jingzhu, Xu Tao, Qian Zhongqing, Wang Hongtao
Department of Biochemistry and Molecular Biology, Bengbu Medical College, Bengbu 233003, China.
Department of Clinical Laboratory, Bengbu Medical College, Bengbu, Anhui 233030, China.
Gastroenterol Res Pract. 2017;2017:7150386. doi: 10.1155/2017/7150386. Epub 2017 Jul 6.
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality worldwide. Host gene variants may influence hepatitis B virus- (HBV-) related HCC. Human leukocyte antigens (HLA) play an important role in presenting virus antigens to immune cells that are responsible for the clearance of virus-infected cells and tumor cells. Previous studies have investigated the HLA-DQ (rs2856718 and rs9275572) polymorphisms that may be associated with the development of HBV-related HCC. However, the results are controversial or inconclusive. Hence, we conducted a meta-analysis to derive a more precise estimation of the associations. A total of 6 articles were used to evaluate the effect of the two polymorphisms on the risk of HBV-related HCC. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. We found that rs2856718 and rs9275572 in HLA-DQ significantly decreased HBV-related HCC in total population, especially in Chinese, but not in Saudi Arabian. Further validation of our results in larger populations and different ethnicities are required.
肝细胞癌（HCC）是全球癌症相关死亡的最常见原因之一。宿主基因变异可能影响乙型肝炎病毒（HBV）相关的HCC。人类白细胞抗原（HLA）在将病毒抗原呈递给负责清除病毒感染细胞和肿瘤细胞的免疫细胞方面发挥着重要作用。先前的研究调查了可能与HBV相关HCC发生相关的HLA-DQ（rs2856718和rs9275572）多态性。然而，结果存在争议或尚无定论。因此，我们进行了一项荟萃分析，以得出更精确的关联估计。总共6篇文章被用于评估这两种多态性对HBV相关HCC风险的影响。计算了比值比（OR）和95%置信区间（95%CI）。我们发现，HLA-DQ中的rs2856718和rs9275572在总体人群中显著降低了HBV相关HCC的发生风险，尤其是在中国人群中，但在沙特阿拉伯人群中并非如此。需要在更大规模人群和不同种族中对我们的结果进行进一步验证。
