Yang Shanshan, Wang Shuang, Yang Bo, Zheng Jinliang, Cai Yuping, Yang Zhengguo
Institute of Geriatrics, Beijing Key Laboratory of Ageing and Geriatrics, State Key Laboratory of Kidney Disease, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.
Jinan Military Area CDC, Jinan, Shandong 250014, China.
J Diabetes Res. 2017;2017:8756978. doi: 10.1155/2017/8756978. Epub 2017 Jul 6.
To investigate the relationship between alcohol consumption and diabetic lower extremity arterial disease (LEAD) in hospitalized patients with type 2 diabetes mellitus (T2DM).
We evaluated 138 hospitalized patients with T2DM who consumed alcohol and 833 who did not. We used propensity score matching to reduce the confounding bias between groups. Additionally, a logistic regression analysis was performed with the matched data to evaluate the LEAD risk.
In total, 119 pairs of patients who did and did not consume alcohol were matched. According to the logistic regression analysis, patients who consumed >8 U of alcohol/day had a higher risk of LEAD (odds ratio (OR): 6.35, 95% confidence interval (CI): 1.78-22.65) than patients who did not consume alcohol. Additionally, after adjusting for age, gender, region, occupation, smoking status, body mass index, weight change, and duration of diabetes, the OR of peripheral artery disease after >20 years of alcohol consumption was 3.48 (95% CI: 1.09-11.15). Furthermore, we observed a significant dose-response relationship between alcohol consumption and LEAD.
Alcohol consumption may be a risk factor of LEAD in patients with T2DM. Patients with T2DM should be advised to stop drinking, to prevent the onset of LEAD.
探讨2型糖尿病（T2DM）住院患者饮酒与糖尿病下肢动脉疾病（LEAD）之间的关系。
我们评估了138例饮酒的T2DM住院患者和833例不饮酒的患者。我们使用倾向评分匹配来减少组间的混杂偏倚。此外，对匹配后的数据进行逻辑回归分析以评估LEAD风险。
总共匹配了119对饮酒和不饮酒的患者。根据逻辑回归分析，每天饮酒量>8单位的患者发生LEAD的风险（比值比（OR）：6.35，95%置信区间（CI）：1.78 - 22.65）高于不饮酒的患者。此外，在调整年龄、性别、地区、职业、吸烟状况、体重指数、体重变化和糖尿病病程后，饮酒超过20年的患者发生外周动脉疾病的OR为3.48（95%CI：1.09 - 11.15）。此外，我们观察到饮酒与LEAD之间存在显著的剂量反应关系。
饮酒可能是T2DM患者发生LEAD的危险因素。应建议T2DM患者戒酒，以预防LEAD的发生。
