Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, People's Republic of China.
PLoS One. 2010 Dec 2;5(12):e15181. doi: 10.1371/journal.pone.0015181.
A low ankle-to-brachial index (ABI) is a strong correlate of cardiovascular disease and subsequent mortality. The relationship between ABI and alcohol consumption remains unclear. Data are from the Cardiovascular Risk Survey (CRS), a multiple-ethnic, community-based, cross-sectional study of 14,618 Chinese people (5757 Hans, 4767 Uygurs, and 4094 Kazakhs) aged 35 years and over at baseline from Oct. 2007 to March 2010. The relationship between alcohol intake and ABI was determined by use of analysis of covariance and multivariable regressions.
In men, alcohol consumption was significantly associated with ABI (P<0.001). After adjusted for the confounding factors, such as age, sex, ethnicity, body mass index, smoking, work stress, diabetes, and fasting blood glucose, the difference remained significant (P<0.001); either the unadjusted or multivariate-adjusted odds ratio (OR) for peripheral artery disease (PAD) was significantly higher in men who consumed >60.0 g/d [OR = 3.857, (95% CI: 2.555-5.824); OR = 2.797, (95% CI: 1.106-3.129); OR = 2.878, (95% CI: 1.215-4.018); respectively] and was significantly lower in men who consumed 20.1-40.0 g/d [OR= 0.330, (95% CI: 0.181-0.599); OR = 0.484, (95% CI: 0.065-0.894); OR = 0.478, (95% CI: 0.243-1.534); respectively] and 40.1-60.0 g/d [OR= 0.306, (95% CI: 0.096-0.969); OR = 0.267, (95% CI: 0.087-0.886); OR = 0.203, (95% CI: 0.113-0.754); respectively] compared with never drinking, respectively (all P<0.01). Neither in unadjusted nor in multivariate-adjusted model was the association between ABI and alcohol consumption significant (all P>0.05) in women. Similarly, PAD was not correlated with alcohol intake in women (all P>0.05).
CONCLUSIONS/SIGNIFICANCE: Our results indicated that in Chinese men, alcohol consumption was associated with peripheral artery disease, and consumption of less than 60 g/d had an inverse association with peripheral atherosclerosis whereas consumption of 60 g/d or more had a positive association.
低踝臂指数（ABI）是心血管疾病和随后死亡的强烈相关因素。ABI 与酒精摄入之间的关系仍不清楚。数据来自心血管风险调查（CRS），这是一项多民族、社区为基础、横断面研究，共纳入了 14618 名年龄在 35 岁及以上的中国人（汉族 5757 人、维吾尔族 4767 人、哈萨克族 4094 人），基线调查时间为 2007 年 10 月至 2010 年 3 月。使用协方差分析和多变量回归来确定酒精摄入量与 ABI 之间的关系。
在男性中，酒精摄入与 ABI 显著相关（P<0.001）。在调整了年龄、性别、种族、体重指数、吸烟、工作压力、糖尿病和空腹血糖等混杂因素后，差异仍然显著（P<0.001）；每天摄入超过 60.0 克酒精的男性患外周动脉疾病（PAD）的未经调整或多变量调整的比值比（OR）分别为 3.857（95%CI：2.555-5.824）、2.797（95%CI：1.106-3.129）和 2.878（95%CI：1.215-4.018）；每天摄入 20.1-40.0 克酒精的男性 OR 分别为 0.330（95%CI：0.181-0.599）、0.484（95%CI：0.065-0.894）和 0.478（95%CI：0.243-1.534）；每天摄入 40.1-60.0 克酒精的男性 OR 分别为 0.306（95%CI：0.096-0.969）、0.267（95%CI：0.087-0.886）和 0.203（95%CI：0.113-0.754）；与从不饮酒相比，差异均具有统计学意义（均 P<0.01）。在未调整和多变量调整模型中，ABI 与酒精摄入之间的关联在女性中均无统计学意义（均 P>0.05）。同样，在女性中，PAD 与酒精摄入无关（均 P>0.05）。
结论/意义：我们的研究结果表明，在中国男性中，酒精摄入与外周动脉疾病有关，每天摄入少于 60 克酒精与外周动脉粥样硬化呈负相关，而每天摄入 60 克或更多酒精与外周动脉粥样硬化呈正相关。
