Jiang Jian Fa, Xiao Song Shu, Xue Min
a From the Department of Obstetrics and Gynecology , The Third Xiangya Hospital of Central South University , Changsha , Hunan , China.
Gynecol Endocrinol. 2018 Jan;34(1):83-86. doi: 10.1080/09513590.2017.1354367. Epub 2017 Aug 1.
Previous studies have shown that alterations of cytokines might play a role in the pathogenesis of adenomyosis. This study aims to investigate the expression of interleukin-37 (IL-37), an anti-inflammatory cytokine, in the eutopic and ectopic endometria of patients with adenomyosis. Endometrial specimens were collected from 30 women with adenomyosis and 20 without adenomyosis. The gene and protein expression of IL-37 was measured using a quantitative real-time polymerase chain reaction and immunohistochemistry, respectively. Compared with the control endometria, the protein expression level and gene level of IL-37 was significantly lower in both the ectopic and eutopic endometria of patients with adenomyosis. The gene and protein expressions of IL-37 in ectopic endometria were lower than those in eutopic endometria of patients with adenomyosis. Our results suggest that there was a low level of IL-37 in the eutopic and ectopic endometria of patients with adenomyosis, and an abnormal inflammatory response might occur in the endometria of patients with adenomyosis.
先前的研究表明，细胞因子的改变可能在子宫腺肌病的发病机制中起作用。本研究旨在调查抗炎细胞因子白细胞介素-37（IL-37）在子宫腺肌病患者在位和异位子宫内膜中的表达。收集了30例子宫腺肌病患者和20例非子宫腺肌病患者的子宫内膜标本。分别采用定量实时聚合酶链反应和免疫组织化学法检测IL-37的基因和蛋白表达。与对照子宫内膜相比，子宫腺肌病患者异位和在位子宫内膜中IL-37的蛋白表达水平和基因水平均显著降低。子宫腺肌病患者异位子宫内膜中IL-37的基因和蛋白表达低于在位子宫内膜。我们的结果表明，子宫腺肌病患者在位和异位子宫内膜中IL-37水平较低，子宫腺肌病患者的子宫内膜可能发生异常炎症反应。
