Kobalava Zh, Troitskaya E, Ezhova N
RUDN, Moscow, Russia.
Kardiologiia. 2017 Apr;57(4):79-88.
High prevalence of arterial hypertension and low rate of blood pressure (BP) control in patients with arterial hypertension require more intensive approaches to antihypertensive therapy. Every patient with arterial hypertension is characterized by different predominant pathophysiologic mechanisms in different periods of his life. Because of impact on different pathophysiologic mechanisms combined antihypertensive therapy allows to achieve more pronounced BP reduction, decrease heterogeneity of response and alleviate side effects of each component. Use of fixed drug combinations improves adherence to treatment and thus its efficacy. Novel fixed-dose combination of amlodipine, indapamide and perindopril fully realizes principles underlying modern antihypertensive therapy. Antihypertensive effectiveness of components of this combination has been confirmed by the results of international trials.
动脉高血压的高患病率以及动脉高血压患者的血压控制率较低，这就需要采取更强化的抗高血压治疗方法。每位动脉高血压患者在其生命的不同阶段都具有不同的主要病理生理机制。由于对不同病理生理机制有影响，联合抗高血压治疗能够实现更显著的血压降低，减少反应的异质性，并减轻每种成分的副作用。使用固定药物组合可提高治疗依从性，从而提高其疗效。氨氯地平、吲达帕胺和培哚普利的新型固定剂量组合充分体现了现代抗高血压治疗的基本原则。该组合各成分的抗高血压有效性已得到国际试验结果的证实。
