Scheen A J, Lancellotti P, Krzesinski J M
Rev Med Liege. 2014 Oct;69(10):565-70.
Triplixam is a fixed dose combination of three well known antihypertensive agents, with complementary activities, to control blood pressure in patients with arterial hypertension: perindopril, an angiotensin converting enzyme inhibitor, indapamide, a diuretic whith thiazide-like effects but also specific properties, and amlodipine, a long-acting calcium antagonist of the dihydropyridine family. The potential synergic action allows better control of blood pressure with once daily administration, while limiting the incidence of adverse events. Various presentations with different dosages are available to facilitate individualized therapy. Warnings and precautions for use of every molecule should of course be respected. Such a fixed dose combination should contribute to limit clinical inertia and to improve therapeutic compliance.
三联降压片是三种知名抗高血压药物的固定剂量组合，具有互补作用，用于控制动脉高血压患者的血压：培哚普利，一种血管紧张素转换酶抑制剂；吲达帕胺，一种具有噻嗪样作用但也有特殊性质的利尿剂；氨氯地平，一种二氢吡啶类长效钙拮抗剂。潜在的协同作用使得每日一次给药就能更好地控制血压，同时限制不良事件的发生率。有各种不同剂量的剂型可供选择，以促进个体化治疗。当然，每种药物使用时的警告和注意事项都应予以遵守。这种固定剂量组合应有助于减少临床惰性并提高治疗依从性。
