de Leon Dianne, Walton Kara, Sokumbi Olayemi
Medical College of Wisconsin, Milwaukee, WI.
Am J Dermatopathol. 2017 Sep;39(9):700-703. doi: 10.1097/DAD.0000000000000965.
Paragangliomas are rare neoplasms that arise from chromaffin cells of the sympathetic and parasympathetic nervous system. These tumors are often cured by surgical resection but the risk for metastatic disease exists, particularly for extra-adrenal paragangliomas. The behavior of these tumors is unpredictable, and clinical and histopathological features associated with malignancy have not been determined. The most common sites of metastases include local and distant lymph nodes, bone, liver, and lung. Cutaneous metastases are exceedingly rare with only 2 reported cases, both of which presented on the scalp. Here we describe a 78-year-old woman with cutaneous metastatic paraganglioma presenting as a forehead nodule, which developed 15 years after her initial diagnosis of paraganglioma.
副神经节瘤是起源于交感和副交感神经系统嗜铬细胞的罕见肿瘤。这些肿瘤通常通过手术切除治愈，但存在转移疾病的风险，尤其是肾上腺外副神经节瘤。这些肿瘤的行为不可预测，与恶性肿瘤相关的临床和组织病理学特征尚未确定。最常见的转移部位包括局部和远处淋巴结、骨骼、肝脏和肺。皮肤转移极为罕见，仅有2例报道，均出现在头皮上。在此，我们描述一名78岁女性，其皮肤转移性副神经节瘤表现为前额结节，在最初诊断为副神经节瘤15年后出现。
