Cho Sooyoung, Shin Aesun, Song Daesub, Park Jae Kyung, Kim Yeonjung, Choi Ji-Yeob, Kang Daehee, Lee Jong-Koo
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University, Seoul, Republic of Korea.
Cancer Epidemiol. 2017 Oct;50(Pt A):16-21. doi: 10.1016/j.canep.2017.07.010. Epub 2017 Jul 29.
To assess the validity of the cohort study participants' self-reported cancer history via data linkage to a cancer registry database.
We included 143,965 participants from the Health Examinees (HEXA) study recruited between 2004 and 2013 who gave informed consent for record linkage to the Korean Central Cancer Registry (KCCR). The sensitivity and the positive predictive value of self-reported histories of cancer were calculated and 95% confidence intervals were estimated.
A total of 4,860 participants who had at least one record in the KCCR were included in the calculation of sensitivity. In addition, 3,671 participants who reported a cancer history at enrollment were included in the calculation of positive predictive value. The overall sensitivity of self-reported cancer history was 72.0%. Breast cancer history among women showed the highest sensitivity (81.2%), whereas the lowest sensitivity was observed for liver cancer (53.7%) and cervical cancer (52.1%). The overall positive predictive value was 81.9%. The highest positive predictive value was observed for thyroid cancer (96.1%) and prostate cancer (96.1%), and the lowest was observed for cervical cancer (43.7%).
The accuracy of self-reported cancer history varied by cancer site and may not be sufficient to ascertain cancer incidence, especially for cervical and bladder cancers.
通过与癌症登记数据库进行数据关联，评估队列研究参与者自我报告的癌症病史的有效性。
我们纳入了2004年至2013年间招募的143,965名健康体检者（HEXA）研究的参与者，他们均已签署知情同意书，同意将记录与韩国中央癌症登记处（KCCR）进行关联。计算了自我报告的癌症病史的敏感性和阳性预测值，并估计了95%置信区间。
共有4860名在KCCR至少有一条记录的参与者被纳入敏感性计算。此外，3671名在入组时报告有癌症病史的参与者被纳入阳性预测值计算。自我报告的癌症病史的总体敏感性为72.0%。女性乳腺癌病史的敏感性最高（81.2%），而肝癌（53.7%）和宫颈癌（52.1%）的敏感性最低。总体阳性预测值为81.9%。甲状腺癌（96.1%）和前列腺癌（96.1%）的阳性预测值最高，而宫颈癌（43.7%）的阳性预测值最低。
自我报告的癌症病史的准确性因癌症部位而异，可能不足以确定癌症发病率，尤其是对于宫颈癌和膀胱癌。
