内源性大麻素在自闭症谱系障碍预防中的神经炎症作用。
Role of Endocannabinoids on Neuroinflammation in Autism Spectrum Disorder Prevention.
作者信息
Habib Syed Shahid, Al-Regaiey Khalid, Bashir Shahid, Iqbal Muhammad
机构信息
Professor, Department of Physiology, King Saud University, Riyadh, Saudi Arabia.
Assistant Professor, Department of Physiology, King Saud University, Riyadh, Saudi Arabia.
出版信息
J Clin Diagn Res. 2017 Jun;11(6):CE01-CE03. doi: 10.7860/JCDR/2017/23862.9969. Epub 2017 Jun 1.
Abstract
Autism Spectrum Disorder (ASD) disease has become a mounting socio-economical alarm around the world. Neuroinflammtion had been shown in postmortem brain specimens from ASD patients. The Endocannabinoids System (ES) consists of a family of locally produced, short-lived, endogenous, phospholipid-derived agonists (endocannabinoids) that control energy balance and body composition. The growing number of medical benefits of ES, such as their ability to regulate processes like neuroinflammation, neurogenesis and memory, raise the question of their potential role as a preventive treatment of ASD. To test this hypothesis, basic and clinical studies allow us a thorough investigation of the role of ES in the pathogenesis of ASD. This hypothesis will help to understand the mechanism of ES and its role in ASD.
摘要
自闭症谱系障碍（ASD）已成为全球日益严重的社会经济警报。在自闭症患者的尸检脑标本中已发现神经炎症。内源性大麻素系统（ES）由一组局部产生、寿命短暂、内源性、磷脂衍生的激动剂（内源性大麻素）组成，这些激动剂控制能量平衡和身体组成。ES的医学益处越来越多，比如它们调节神经炎症、神经发生和记忆等过程的能力，这引发了它们作为自闭症预防性治疗潜在作用的问题。为了验证这一假设，基础研究和临床研究使我们能够深入探究ES在自闭症发病机制中的作用。这一假设将有助于理解ES的机制及其在自闭症中的作用。
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