Zou Mingyang, Li Dexin, Li Ling, Wu Lijie, Sun Caihong
Department of Children's and Adolescent Health, Public Health College, Harbin Medical University, Harbin, 150081, China.
Int J Dev Neurosci. 2019 Aug;76:95-102. doi: 10.1016/j.ijdevneu.2019.03.002. Epub 2019 Mar 8.
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that begins in infancy. Although the etiology and pathogenesis are poorly understood, many studies have shown that ASD is closely related to structural and functional defects in the nervous system, especially synaptic transmission. The endocannabinoid (eCB) system is an important regulatory system of the central nervous system that regulates neurotransmission and synaptic plasticity and plays an important role in emotional and social responses and cognitive function. The relationship between eCB system and ASD has attracted increasing attention from scholars. In this review, we discuss the complex lipid signaling network of the eCB system, intracellular transport pathways, abnormal expression and association with various neurological diseases, and direct and indirect evidence for the link between eCB and ASD. Collectively, the findings to date indicate that the eCB system plays a key role in the pathophysiology of ASD and can provide new insights into potential interventions and rehabilitation strategies for ASD.
自闭症谱系障碍（ASD）是一种始于婴儿期的复杂神经发育障碍。尽管其病因和发病机制尚不清楚，但许多研究表明，ASD与神经系统的结构和功能缺陷密切相关，尤其是突触传递。内源性大麻素（eCB）系统是中枢神经系统的重要调节系统，可调节神经传递和突触可塑性，并在情绪和社交反应以及认知功能中发挥重要作用。eCB系统与ASD之间的关系已引起学者们越来越多的关注。在本综述中，我们讨论了eCB系统复杂的脂质信号网络、细胞内运输途径、异常表达以及与各种神经疾病的关联，以及eCB与ASD之间联系的直接和间接证据。总体而言，迄今为止的研究结果表明，eCB系统在ASD的病理生理学中起关键作用，并可为ASD的潜在干预措施和康复策略提供新的见解。
