生长抑素选择性增强大鼠海马体和皮质中乙酰胆碱诱导的兴奋作用。
Somatostatin selectively enhances acetylcholine-induced excitations in rat hippocampus and cortex.
作者信息
Mancillas J R, Siggins G R, Bloom F E
出版信息
Proc Natl Acad Sci U S A. 1986 Oct;83(19):7518-21. doi: 10.1073/pnas.83.19.7518.
Abstract
The neuronal effects of somatostatin-14 (SS-14) and its influence on responses to acetylcholine (AcCho) were studied in vivo in the rat parietal cortex and dorsal hippocampus, using single-unit recording and microiontophoresis. SS-14 inhibited spontaneous firing of nearly all cells tested, while AcCho facilitated their firing. In contrast to its direct slowing effect, sustained iontophoretic application of SS-14 enhanced AcCho-induced excitations in 78% of all cells tested. This AcCho-enhancing effect of SS-14 was dose dependent. SS-14 did not enhance the responsiveness to pulses of the excitatory amino acid glutamate. Neurons tonically driven by iontophoretic currents of AcCho responded to concurrent pulses of SS-14 with an increase in firing. Thus, iontophoretic application of SS-14 can produce qualitatively different effects on the spontaneous activity of its target cells depending on the simultaneous effects of other chemical messengers. These condition-dependent interactions may explain the diverse neuronal effects of SS-14 reported in the literature.
摘要
采用单单位记录和微离子透入法，在大鼠顶叶皮层和背侧海马体内研究了生长抑素-14（SS-14）的神经元效应及其对乙酰胆碱（AcCho）反应的影响。SS-14抑制了几乎所有被测试细胞的自发放电，而AcCho则促进了它们的放电。与其直接的减慢效应相反，持续离子透入应用SS-14增强了78%的被测试细胞中AcCho诱导的兴奋。SS-14的这种增强AcCho的效应是剂量依赖性的。SS-14没有增强对兴奋性氨基酸谷氨酸脉冲的反应性。由AcCho的离子透入电流持续驱动的神经元对同时施加的SS-14脉冲反应为放电增加。因此，根据其他化学信使的同时作用，离子透入应用SS-14可对其靶细胞的自发活动产生质的不同的影响。这些条件依赖性相互作用可能解释了文献中报道的SS-14的多种神经元效应。
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