Powell D A, Buchanan S L
Pharmacol Biochem Behav. 1986 Aug;25(2):423-30. doi: 10.1016/0091-3057(86)90019-5.
Chronic indwelling cannulas were implanted in the mediodorsal nucleus (MD) of the thalamus in New Zealand albino rabbits. Heart rate (HR), blood pressure (BP), respiration and electromyographic activity (EMG) were recorded subsequent to the injection of saline, l-glutamate, or carbachol through the previously implanted cannulas. Dose related decreases in HR and increases in BP were obtained after administration of both l-glutamate and carbachol at doses in the micromolar range. Control injections through cannulas chronically implanted in the overlying hippocampus or adjacent ventricles resulted in dramatic HR and BP baseline changes in a parasympathetic direction (viz HR and BP decreases) suggesting that the effects obtained with MD placements were due to chemical stimulation of MD. Responses elicited from MD in the present experiment were similar, but not identical, to those produced by electrical stimulation of MD, suggesting that the latter effects were not due to stimulation of fibers of passage.
在新西兰白化兔的丘脑背内侧核（MD）植入慢性留置套管。通过先前植入的套管注射生理盐水、L-谷氨酸或卡巴胆碱后，记录心率（HR）、血压（BP）、呼吸和肌电图活动（EMG）。在以微摩尔范围的剂量给予L-谷氨酸和卡巴胆碱后，均观察到心率与剂量相关的降低以及血压升高。通过长期植入覆盖海马体或相邻脑室的套管进行对照注射，导致心率和血压基线朝着副交感神经方向发生显著变化（即心率和血压降低），这表明MD植入所获得的效应是由于对MD的化学刺激。本实验中从MD引发的反应与MD电刺激所产生的反应相似但不完全相同，这表明后者的效应并非由于对传导纤维的刺激。
