Buchanan S L, Valentine J, Powell D A
Behav Brain Res. 1985 Oct-Nov;18(1):51-62. doi: 10.1016/0166-4328(85)90168-8.
Conscious rabbits received electrical stimulation of the anterior midline frontal cortex or lateral somatosensory and motor cortex, through chronically-implanted electrodes. Active sites for cardiovascular responses were found in the anterior midline cortex, but stimulation of the frontolateral sensory-motor cortex either did not elicit cardiovascular changes or elicited only small and variable changes when stimulated. The heart-rate response elicited was, in all cases, bradycardia. All blood pressure changes consisted of depressor responses. Stimulation of the lateral frontal cortex almost always resulted in increases in EMG activity, although many placements were observed in the medial frontal cortex that were unaccompanied by movement. In all cases in which depressor responses and bradycardia were elicited, increases in respiration rate and decreases in depth also occurred. The active area from which bradycardia and depressor responses were elicited forms the medial portion of the cortical projection area of the mediodorsal nucleus of the thalamus and thus may be involved in the autonomic accompaniments of the behavioral activities, i.e. learning and memory processes, associated with this nucleus.
清醒的兔子通过长期植入的电极接受前正中额叶皮层或外侧体感和运动皮层的电刺激。在前正中皮层发现了心血管反应的活性位点，但刺激额外侧感觉运动皮层要么不引起心血管变化，要么在刺激时仅引起微小且多变的变化。在所有情况下，引发的心率反应均为心动过缓。所有血压变化均为降压反应。刺激外侧额叶皮层几乎总是导致肌电图活动增加，尽管在内侧额叶皮层观察到许多部位未伴随运动。在所有引发降压反应和心动过缓的情况下，呼吸频率也会增加，深度会降低。引发心动过缓和降压反应的活性区域形成丘脑背内侧核皮层投射区域的内侧部分，因此可能参与与该核相关的行为活动（即学习和记忆过程）的自主伴随活动。
