Gawin F H
Psychopharmacology (Berl). 1986;90(1):142-3. doi: 10.1007/BF00172886.
Central dopaminergic activation is hypothesized to underly schizophrenia and, paradoxically, stimulant euphoria. Four cocaine abusers with histories of stimulant-induced paranoid psychoses reported selective reduction in psychotic symptoms but not euphoria when treated with dopamine blockers. This provides preliminary evidence against efficacy of neuroleptics in cocaine abuse prevention, and suggests euphoria and paranoia may have discriminable neurophysiological substrates.
中枢多巴胺能激活被认为是精神分裂症以及矛盾的是，兴奋剂所致欣快感的基础。四名有兴奋剂诱发偏执性精神病病史的可卡因滥用者报告称，在使用多巴胺阻滞剂治疗时，精神病性症状有选择性减轻，但欣快感未减轻。这为抗精神病药物在预防可卡因滥用方面的疗效提供了初步反证，并表明欣快感和偏执可能有可区分的神经生理底物。
