Loerz Christine, Maser Edmund
Institute of Toxicology and Pharmacology for Natural Scientists, University Medical School Schleswig-Holstein, Kiel, Germany.
Institute of Toxicology and Pharmacology for Natural Scientists, University Medical School Schleswig-Holstein, Kiel, Germany.
J Steroid Biochem Mol Biol. 2017 Nov;174:65-71. doi: 10.1016/j.jsbmb.2017.07.030. Epub 2017 Jul 29.
The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) contributes to intracellular glucocorticoid action by converting inactive cortisone to its receptor-active form cortisol (11-dehydrocorticosterone and corticosterone in mice and rats). The potential role of 11β-HSD1 in the pathogenesis of the metabolic syndrome has emerged over the past three decades. However, the precise impact of 11β-HSD1 in obesity-related diseases remains uncertain. Many studies from animal experiments to clinical studies have investigated liver and adipose tissue 11β-HSD1 in relation to obesity and its metabolic disorders including insulin resistance. But the relevance of 11β-HSD1 in skeletal muscle has been less extensively studied. On the other hand, skeletal muscle is assumed to be the main site of peripheral insulin resistance, but the biological relevance of 11β-HSD1 in skeletal muscle is unclear. This mini-review will focus on 11β-HSD1 in skeletal muscle and its postulated link to obesity and insulin-resistance.
11β-羟基类固醇脱氢酶1型（11β-HSD1）通过将无活性的可的松转化为其受体活性形式的皮质醇（小鼠和大鼠体内为11-脱氢皮质酮和皮质酮）来促进细胞内糖皮质激素的作用。在过去三十年中，11β-HSD1在代谢综合征发病机制中的潜在作用逐渐显现。然而，11β-HSD1在肥胖相关疾病中的精确影响仍不确定。从动物实验到临床研究的许多研究都调查了肝脏和脂肪组织中的11β-HSD1与肥胖及其代谢紊乱（包括胰岛素抵抗）的关系。但11β-HSD1在骨骼肌中的相关性研究较少。另一方面，骨骼肌被认为是外周胰岛素抵抗的主要部位，但11β-HSD1在骨骼肌中的生物学相关性尚不清楚。本综述将聚焦于骨骼肌中的11β-HSD1及其与肥胖和胰岛素抵抗的假定联系。
