Gezer Naciye Sinem, Balcı Ali, Kalemci Orhan, Köremezli Nevin, Başara Akın Işıl, Ur Koray
Department of Radiology, Dokuz Eylül University School of Medicine, İzmir, Turkey.
Diagn Interv Radiol. 2017 Sep-Oct;23(5):385-389. doi: 10.5152/dir.2017.16463.
Spondylolysis is known to be a part of a disease process, which describes a defect in the pars interarticularis of vertebra. We aimed to use quantitative computed tomography (QCT) to measure vertebral body bone mineral density (BMD) in patients with lumbar spondylolysis and compare it with readings in controls.
Forty symptomatic patients with lumbar spondylolysis aged 18-52 years and 40 matched controls of same sex and approximate age (±2 years) were included in the study. Measurements of BMD were performed by QCT analysis for each vertebral body from T12 to L5 and mean BMD was calculated for each case.
Of 40 patients, 22 (55%) demonstrated L5 spondylolysis, 14 (35%) L4 spondylolysis, three (7.5%) L3 spondylolysis, and one (2.5%) L2 spondylolysis. Spondylolisthesis was found in 29 patients (73%). Patients with spondylolisthesis were significantly older than patients without spondylolisthesis (42±6.9 vs. 37.2±5.4, P = 0.024). Mean BMD value of the patient group was significantly lower than that of the controls (105±24 mg/cm³ vs. 118.7±25.6 mg/cm³, P = 0.015). Subgroup analysis of 19 patients and 19 controls under the age of 40 revealed that the mean BMD value of the patients was significantly lower than that of the controls in the younger age group as well (108.7±23.5 mg/cm³ vs. 130±25.8 mg/cm³, P = 0.009).
This study demonstrated that patients with spondylolysis had significantly lower mean vertebral body BMD compared with controls.
已知椎弓根峡部裂是疾病过程的一部分，该疾病过程描述了椎骨关节突间部的缺陷。我们旨在使用定量计算机断层扫描（QCT）测量腰椎椎弓根峡部裂患者的椎体骨密度（BMD），并将其与对照组的读数进行比较。
本研究纳入了40例年龄在18 - 52岁的有症状的腰椎椎弓根峡部裂患者以及40例性别相同、年龄相近（±2岁）的匹配对照组。通过QCT分析对从T12到L5的每个椎体进行BMD测量，并计算每个病例的平均BMD。
40例患者中，22例（55%）表现为L5椎弓根峡部裂，14例（35%）为L4椎弓根峡部裂，3例（7.5%）为L3椎弓根峡部裂，1例（2.5%）为L2椎弓根峡部裂。29例患者（73%）发现有椎体滑脱。有椎体滑脱的患者明显比没有椎体滑脱的患者年龄大（42±6.9岁对37.2±5.4岁，P = 0.024）。患者组的平均BMD值明显低于对照组（105±24mg/cm³对118.7±25.6mg/cm³，P = 0.015）。对19例年龄在40岁以下的患者和19例对照组进行亚组分析发现，在较年轻的年龄组中，患者的平均BMD值也明显低于对照组（108.7±23.5mg/cm³对130±25.8mg/cm³，P = 0.009）。
本研究表明，与对照组相比，椎弓根峡部裂患者的平均椎体BMD明显更低。
