Verma Rajesh, Garg Vipul
Department of Neurology, King George's Medical University, Lucknow, Uttar Pradesh, India.
King George's Medical University, Lucknow, Uttar Pradesh, India.
BMJ Case Rep. 2017 Jul 31;2017:bcr-2017-219905. doi: 10.1136/bcr-2017-219905.
Wernicke's encephalopathy is a rare neurological disorder caused by thiamine deficiency, characterised by ocular motor dysfunction, ataxia and impairment in consciousness. It predominantly affects brain regions with a high metabolic rate such as mammillary bodies, medial thalamic nuclei, the tectal region and the cerebellum. Although chronic alcoholism is the most common cause of Wernicke's encephalopathy, various other conditions not related to alcohol consumption such as bariatric surgery, acute pancreatitis, hyperemesis gravidarum, prolonged fasting and gastrointestinal surgery have been implicated in its aetiology. We report the case of a patient who underwent surgery for liver abscess and subsequently developed Wernicke's encephalopathy; he showed a positive response to thiamine supplementation. This is the first report describing liver abscess as the cause of Wernicke's encephalopathy.
韦尼克脑病是一种由硫胺素缺乏引起的罕见神经系统疾病，其特征为眼球运动功能障碍、共济失调和意识障碍。它主要影响代谢率高的脑区，如乳头体、丘脑内侧核、顶盖区和小脑。虽然慢性酒精中毒是韦尼克脑病最常见的病因，但其他各种与饮酒无关的情况，如减肥手术、急性胰腺炎、妊娠剧吐、长期禁食和胃肠道手术，也被认为与该病的病因有关。我们报告了一例因肝脓肿接受手术，随后发生韦尼克脑病的患者；他对补充硫胺素表现出积极反应。这是第一份将肝脓肿描述为韦尼克脑病病因的报告。
