Senior Resident, Department of Obstetric Medicine, Fernandez Hospital, Hyderabad, India.
Consultant Physician, Department of Obstetric Medicine, Fernandez Hospital, Hyderabad, India.
Trop Doct. 2022 Jan;52(1):98-100. doi: 10.1177/00494755211014396. Epub 2021 Jun 24.
Whilst nausea affects around 80% of pregnant women, hyperemesis gravidarum, an extreme form of the same, affects only 0.5% to 3%, but may lead to severe nutritional deficiency. Wernicke's encephalopathy is an acute neuropsychiatric disorder which occurs due to thiamine deficiency and needs emergency treatment to prevent neurological morbidity and mortality. Wernicke's encephalopathy is characterised by a clinical triad of oculomotor abnormalities, cerebellar dysfunction and altered mental state. Korsakoff's psychosis is a chronic condition and consequence of Wernicke's encephalopathy, resulting from its delayed treatment. Wernicke's encephalopathy is a well-known complication of chronic alcohol abuse. Not many are aware of its association with hyperemesis gravidarum. Although it is a rare complication, if not diagnosed and treated promptly, it may result in permanent and irreversible neurological sequelae. The objective of our retrospective observational study was to analyse the clinical profile and outcome (short and long term) in a rare yet preventable complication of pregnancy.
虽然恶心影响了大约 80%的孕妇，但妊娠剧吐，一种同样的极端形式，只影响 0.5%至 3%，但可能导致严重的营养缺乏。Wernicke 脑病是一种由于硫胺素缺乏引起的急性神经精神障碍，需要紧急治疗以防止神经发病率和死亡率。Wernicke 脑病的特征是眼球运动异常、小脑功能障碍和精神状态改变的三联征。柯萨科夫精神病是 Wernicke 脑病的慢性并发症，是由于其延迟治疗所致。Wernicke 脑病是慢性酒精滥用的一种常见并发症。并非很多人都知道它与妊娠剧吐有关。虽然它是一种罕见的并发症，但如果不及时诊断和治疗，可能会导致永久性和不可逆转的神经后遗症。我们回顾性观察研究的目的是分析一种罕见但可预防的妊娠并发症的临床特征和结局（短期和长期）。
