Pahwa S
Vox Sang. 1986;51 Suppl 2:33-8. doi: 10.1111/j.1423-0410.1986.tb02005.x.
The etiologic agent for acquired immune deficiency syndrome (AIDS) has been identified as human T lymphotropic virus type III (HTLV-III). Its distinguishing characteristics and putative receptor, the T4 molecule, are discussed. The Western Blot method has been applied to assess the presence of antibody to HTLV-III in patients as a measure of infection with HTLV-III. The definition of AIDS in children, based on the Centers for Disease Control surveillance criteria, is explored and expanded. Clinical and laboratory manifestations of pediatric AIDS are explained in the context of 'HTLV-III infection' through an analysis of prospective and retrospective serologic studies. Transmission of the disease is explored through parental history of infected children. Finally, the rationale for antibody replacement therapy is set forth.
获得性免疫缺陷综合征（艾滋病）的病原体已被确定为人类嗜T淋巴细胞病毒III型（HTLV-III）。文中讨论了其独特特征及假定受体T4分子。已应用免疫印迹法评估患者体内抗HTLV-III抗体的存在情况，以此作为感染HTLV-III的一种检测手段。探讨并扩展了基于疾病控制中心监测标准的儿童艾滋病定义。通过对前瞻性和回顾性血清学研究的分析，在“HTLV-III感染”背景下解释了儿童艾滋病的临床和实验室表现。通过受感染儿童的父母病史探究了该疾病的传播情况。最后，阐述了抗体替代疗法的基本原理。
