Conceptual Immunology Group, The Salk Institute, 10010 N. Torrey Pines Rd, La Jolla, CA, 92037, USA.
Immunol Res. 2017 Oct;65(5):977-981. doi: 10.1007/s12026-017-8941-z.
As the data accumulates, it becomes obvious that the Standard Model of TCR structure-function relationships is in jeopardy. The proposed Tritope model has become more meaningful and, in any case, is richer in prediction and explanation. This is illustrated here by using the signaling interactions of the TCR as examples. An unsuspected signaling pathway for positive selection, and for alloreactivity, is predicted. Further, crucial data needed to elucidate the structural elements that distinguish signaling for restrictive- versus allo-reactivity are identified.
随着数据的积累，TCR 结构-功能关系的标准模型显然处于危险之中。拟议的三肽模型变得更有意义，而且无论如何，在预测和解释方面更加丰富。这里通过使用 TCR 的信号转导相互作用作为例子来说明。预测了阳性选择和同种异体反应的一个意想不到的信号通路。此外，还确定了阐明区分限制性和同种异体反应信号的结构要素所需的关键数据。
