• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

T细胞对抗原限制性识别的三表位模型II. 对个体发育、进化和生理学的意义

The Tritope Model for restrictive recognition of antigen by T-cells II. Implications for ontogeny, evolution and physiology.

作者信息

Cohn Melvin

机构信息

Conceptual Immunology Group, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, United States.

出版信息

Mol Immunol. 2008 Feb;45(3):632-52. doi: 10.1016/j.molimm.2006.02.033. Epub 2007 Sep 21.

DOI:10.1016/j.molimm.2006.02.033
PMID:17889366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2104471/
Abstract

Based on the Tritope Model of the TCR [Cohn, M., 2005c. The Tritope Model for restrictive recognition of antigen by T-cells. I. What assumptions about structure are needed to explain function? Mol. Immunol. 42, 1419-1443], a set of functional and evolutionary problems surrounding restrictive recognition of antigen are discussed. These include the origin of allele-specific recognition, the selection pressures for polygeneism and polymorphism, the TCR signaling interactions, the centrality of effector T-helper (eTh)-dependence for activation, the role of haplotype exclusion, "nonclassical" MHC-elements, alloreactivity versus xenoreactivity, etc. Further, a set of observations believed to support the Standard Model are reinterpreted.

摘要

基于TCR的三表位模型[科恩，M.，2005年c。T细胞对抗原限制性识别的三表位模型。I. 解释功能需要哪些关于结构的假设？分子免疫学。42，1419 - 1443]，讨论了围绕抗原限制性识别的一系列功能和进化问题。这些问题包括等位基因特异性识别的起源、多基因性和多态性的选择压力、TCR信号相互作用、效应性辅助性T细胞（eTh）依赖性激活的核心地位、单倍型排斥的作用、“非经典”MHC元件、同种异体反应性与异种反应性等。此外，对一组被认为支持标准模型的观察结果进行了重新解释。

相似文献

1
The Tritope Model for restrictive recognition of antigen by T-cells II. Implications for ontogeny, evolution and physiology.T细胞对抗原限制性识别的三表位模型II. 对个体发育、进化和生理学的意义
Mol Immunol. 2008 Feb;45(3):632-52. doi: 10.1016/j.molimm.2006.02.033. Epub 2007 Sep 21.
2
The Tritope Model for restrictive recognition of antigen by T-cells I. What assumptions about structure are needed to explain function?T细胞对抗原进行限制性识别的三表位模型 一、为解释功能需要对结构做哪些假设？
Mol Immunol. 2005 Aug;42(12):1419-43. doi: 10.1016/j.molimm.2005.01.013. Epub 2005 Feb 26.
3
Signaling interactions predicted by the Tritope model of the TCR.TCR 三聚体模型预测的信号转导相互作用。
Immunol Res. 2017 Oct;65(5):977-981. doi: 10.1007/s12026-017-8941-z.
4
Is the Framework of Cohn's 'Tritope Model' for How T Cell Receptors Recognize Peptide/Self-MHC Complexes and Allo-MHC Plausible?科恩关于T细胞受体如何识别肽/自身MHC复合物及同种异体MHC的“三表位模型”框架合理吗？
Scand J Immunol. 2016 May;83(5):311-3. doi: 10.1111/sji.12421.
5
Tritope model of restrictive recognition by the TCR.TCR限制性识别的三表位模型。
Trends Immunol. 2003 Mar;24(3):127-31. doi: 10.1016/s1471-4906(03)00021-8.
6
Dissecting the two models of TCR structure-function relationships.剖析TCR结构-功能关系的两种模型。
Immunol Res. 2016 Aug;64(4):795-803. doi: 10.1007/s12026-016-8796-8.
7
Mathematical modeling of helper T lymphocyte/antigen-presenting cell interactions: analysis of methods for modifying antigen processing and presentation.辅助性T淋巴细胞/抗原呈递细胞相互作用的数学建模：抗原加工与呈递修饰方法分析
J Theor Biol. 1996 Oct 21;182(4):487-504. doi: 10.1006/jtbi.1996.0190.
8
An observation that illustrates most T cell receptor structure-function relationships.阐明大多数 T 细胞受体结构-功能关系的观察结果。
Immunol Res. 2017 Dec;65(6):1095-1098. doi: 10.1007/s12026-017-8958-3.
9
Regulatory T cells and co-evolution of allele-specific MHC recognition by the TCR.调节性 T 细胞与 TCR 对 MHC 等位基因特异性识别的共同进化。
Scand J Immunol. 2020 Mar;91(3):e12853. doi: 10.1111/sji.12853. Epub 2019 Dec 17.
10
Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition.基于抗原切割、MHCII 呈递和 TCR 识别预测 CD4 T 细胞表位。
PLoS One. 2018 Nov 6;13(11):e0206654. doi: 10.1371/journal.pone.0206654. eCollection 2018.

引用本文的文献

1
Signaling interactions predicted by the Tritope model of the TCR.TCR 三聚体模型预测的信号转导相互作用。
Immunol Res. 2017 Oct;65(5):977-981. doi: 10.1007/s12026-017-8941-z.
2
Why rethink the structure-function relationships regulating TCR behavior?为何要重新思考调节TCR行为的结构-功能关系？
Curr Trends Immunol. 2009;10:105-111.
3
Ten experiments that would make a difference in understanding immune mechanisms.十种可能改变免疫机制理解的实验。
Cell Mol Life Sci. 2012 Feb;69(3):405-12. doi: 10.1007/s00018-011-0869-1. Epub 2011 Nov 1.
4
On the logic of restrictive recognition of peptide by the T-cell antigen receptor.T 细胞抗原受体对肽的限制性识别的逻辑。
Immunol Res. 2011 May;50(1):49-68. doi: 10.1007/s12026-010-8173-y.
5
The discussion with Jacques Miller: illustrating the limitations of pure empiricism.与雅克·米勒的讨论：阐明纯粹经验主义的局限性。
Immunol Cell Biol. 2009 Aug-Sep;87(6):435-7. doi: 10.1038/icb.2009.34. Epub 2009 May 12.
6
On the opposing views of the self-nonself discrimination by the immune system.关于免疫系统对自身与非自身识别的对立观点。
Immunol Cell Biol. 2009 Feb;87(2):113-9, discussion 120-1. doi: 10.1038/icb.2008.96. Epub 2008 Dec 2.
7
What roles do regulatory T cells play in the control of the adaptive immune response?调节性T细胞在适应性免疫反应的调控中发挥着什么作用？
Int Immunol. 2008 Sep;20(9):1107-18. doi: 10.1093/intimm/dxn088. Epub 2008 Jul 25.
8
A hypothesis accounting for the paradoxical expression of the D gene segment in the BCR and the TCR.一种解释BCR和TCR中D基因片段矛盾性表达的假说。
Eur J Immunol. 2008 Jul;38(7):1779-87. doi: 10.1002/eji.200738089.
9
What does the T-cell receptor recognize when it docks on an MHC-encoded restricting element?当T细胞受体与主要组织相容性复合体（MHC）编码的限制元件结合时，它识别的是什么？
Mol Immunol. 2008 Jun;45(11):3264-7. doi: 10.1016/j.molimm.2008.02.016. Epub 2008 Apr 3.
10
An in depth analysis of the concept of "polyspecificity" assumed to characterize TCR/BCR recognition.对假定为TCR/BCR识别特征的“多特异性”概念进行深入分析。
Immunol Res. 2008;40(2):128-47. doi: 10.1007/s12026-007-8003-z.

本文引用的文献

1
On the logic of positive selection.论正向选择的逻辑。
Immunology. 2006 Apr;117(4):452-3. doi: 10.1111/j.1365-2567.2006.02328.x.
2
Deconstructing the form and function of the TCR/CD3 complex.解析TCR/CD3复合物的形式与功能。
Immunity. 2006 Feb;24(2):133-9. doi: 10.1016/j.immuni.2006.01.006.
3
I-Ep-bound self-peptides: identification, characterization, and role in alloreactivity.
J Immunol. 2006 Jan 15;176(2):1062-71. doi: 10.4049/jimmunol.176.2.1062.
4
What are the commonalities governing the behavior of humoral immune recognitive repertoires?调控体液免疫识别库行为的共性是什么？
Dev Comp Immunol. 2006;30(1-2):19-42. doi: 10.1016/j.dci.2005.06.015.
5
Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function.αβ细胞毒性T细胞对Hfe的直接识别，Hfe是一种无抗原呈递功能的Ib类主要组织相容性复合体分子。
Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12855-60. doi: 10.1073/pnas.0502309102. Epub 2005 Aug 25.
6
How the T cell receptor sees antigen--a structural view.T细胞受体如何识别抗原——结构视角
Cell. 2005 Aug 12;122(3):333-6. doi: 10.1016/j.cell.2005.07.015.
7
The Tritope Model for restrictive recognition of antigen by T-cells I. What assumptions about structure are needed to explain function?T细胞对抗原进行限制性识别的三表位模型 一、为解释功能需要对结构做哪些假设？
Mol Immunol. 2005 Aug;42(12):1419-43. doi: 10.1016/j.molimm.2005.01.013. Epub 2005 Feb 26.
8
A biological context for the self-nonself discrimination and the regulation of effector class by the immune system.免疫系统进行自我与非自我识别以及效应器类别调节的生物学背景。
Immunol Res. 2005;31(2):133-50. doi: 10.1385/IR:31:2:133.
9
Degeneracy, mimicry and crossreactivity in immune recognition.免疫识别中的简并性、模拟与交叉反应性。
Mol Immunol. 2005 Mar;42(5):651-5. doi: 10.1016/j.molimm.2004.09.010.
10
An alternative to current thinking about positive selection, negative selection and activation of T cells.一种与当前关于T细胞阳性选择、阴性选择和激活的观点不同的看法。
Immunology. 2004 Apr;111(4):375-80. doi: 10.1111/j.0019-2805.2004.01830.x.