T细胞对抗原限制性识别的三表位模型II. 对个体发育、进化和生理学的意义
The Tritope Model for restrictive recognition of antigen by T-cells II. Implications for ontogeny, evolution and physiology.
作者信息
Cohn Melvin
机构信息
Conceptual Immunology Group, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, United States.
出版信息
Mol Immunol. 2008 Feb;45(3):632-52. doi: 10.1016/j.molimm.2006.02.033. Epub 2007 Sep 21.
Abstract
Based on the Tritope Model of the TCR [Cohn, M., 2005c. The Tritope Model for restrictive recognition of antigen by T-cells. I. What assumptions about structure are needed to explain function? Mol. Immunol. 42, 1419-1443], a set of functional and evolutionary problems surrounding restrictive recognition of antigen are discussed. These include the origin of allele-specific recognition, the selection pressures for polygeneism and polymorphism, the TCR signaling interactions, the centrality of effector T-helper (eTh)-dependence for activation, the role of haplotype exclusion, "nonclassical" MHC-elements, alloreactivity versus xenoreactivity, etc. Further, a set of observations believed to support the Standard Model are reinterpreted.
摘要
基于TCR的三表位模型[科恩，M.，2005年c。T细胞对抗原限制性识别的三表位模型。I. 解释功能需要哪些关于结构的假设？分子免疫学。42，1419 - 1443]，讨论了围绕抗原限制性识别的一系列功能和进化问题。这些问题包括等位基因特异性识别的起源、多基因性和多态性的选择压力、TCR信号相互作用、效应性辅助性T细胞（eTh）依赖性激活的核心地位、单倍型排斥的作用、“非经典”MHC元件、同种异体反应性与异种反应性等。此外，对一组被认为支持标准模型的观察结果进行了重新解释。
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本文引用的文献
1
On the logic of positive selection.论正向选择的逻辑。
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2
Deconstructing the form and function of the TCR/CD3 complex.解析TCR/CD3复合物的形式与功能。
Immunity. 2006 Feb;24(2):133-9. doi: 10.1016/j.immuni.2006.01.006.
3
I-Ep-bound self-peptides: identification, characterization, and role in alloreactivity.
J Immunol. 2006 Jan 15;176(2):1062-71. doi: 10.4049/jimmunol.176.2.1062.
4
What are the commonalities governing the behavior of humoral immune recognitive repertoires?调控体液免疫识别库行为的共性是什么？
Dev Comp Immunol. 2006;30(1-2):19-42. doi: 10.1016/j.dci.2005.06.015.
5
Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function.αβ细胞毒性T细胞对Hfe的直接识别，Hfe是一种无抗原呈递功能的Ib类主要组织相容性复合体分子。
Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12855-60. doi: 10.1073/pnas.0502309102. Epub 2005 Aug 25.
6
How the T cell receptor sees antigen--a structural view.T细胞受体如何识别抗原——结构视角
Cell. 2005 Aug 12;122(3):333-6. doi: 10.1016/j.cell.2005.07.015.
7
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8
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9
Degeneracy, mimicry and crossreactivity in immune recognition.免疫识别中的简并性、模拟与交叉反应性。
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10
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Immunology. 2004 Apr;111(4):375-80. doi: 10.1111/j.0019-2805.2004.01830.x.
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