Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, PR China.
Future Oncol. 2017 Sep;13(21):1883-1891. doi: 10.2217/fon-2017-0180. Epub 2017 Aug 2.
The prognostic role of p53 protein expression in osteosarcoma has been reported, but the results remain conflicting.
MATERIALS & METHODS: The relevant literature databases were searched to get eligible articles published in English. The overall ORs or HRs and their corresponding 95% CIs were calculated.
The results indicated that p53 protein expression was not linked to age factor, gender, tumor grade, cancer metastasis and response to chemotherapy. p53 expression was significantly lower in osteogenic osteosarcoma than in nonosteogenic osteosarcoma (OR = 0.40; p = 0.006). p53 expression was associated with a poor prognosis of patients in overall survival (univariate analysis: HR: 2.49; p < 0.001 and multivariate analysis: HR: 2.92; p < 0.001).
p53 expression was correlated with pathological type and may become a useful prognostic biomarker in overall survival in osteosarcoma.
已有研究报道 p53 蛋白表达在骨肉瘤中的预后作用，但结果仍存在争议。
检索相关英文文献数据库，获取符合条件的已发表文献。计算总比值比（OR）或风险比（HR）及其相应的 95%置信区间（CI）。
结果表明，p53 蛋白表达与年龄因素、性别、肿瘤分级、癌症转移和化疗反应无关。成骨型骨肉瘤中 p53 表达明显低于非成骨型骨肉瘤（OR=0.40；p=0.006）。p53 表达与患者总生存预后不良相关（单因素分析：HR：2.49；p<0.001，多因素分析：HR：2.92；p<0.001）。
p53 表达与病理类型相关，可能成为骨肉瘤总生存预后的有用生物标志物。
