Anhui Chest Hospital, 397 Jixi Road, Hefei, 230022, China.
Materials Genome Institute, Shanghai University, Shanghai, 201800, China.
Biomed Eng Online. 2021 Mar 2;20(1):24. doi: 10.1186/s12938-021-00860-0.
Osteosarcoma (OS) is the most common primary bone malignancy that affects children and young adults. OS is characterized by a high degree of malignancy, strong invasiveness, rapid disease progression, and extremely high mortality rate; it is considered as a serious threat to the human health globally. The incidence of OS is common in the metaphysis of long tubular bones, but rare in the spine, pelvis, and sacrum areas; moreover, majority of the OS patients present with only a single lesion. OS has a bimodal distribution pattern, that is, its incidence peaks in the second decade of life and in late adulthood. We examine historical and current literature to present a succinct review of OS. In this review, we have discussed the types, clinical diagnosis, and modern and future treatment methods of OS. The purpose of this article is to inspire new ideas to develop more effective therapeutic options.
骨肉瘤（OS）是一种常见的原发性骨恶性肿瘤，主要影响儿童和青少年。OS 具有高度恶性、强侵袭性、疾病进展迅速和极高死亡率的特点，被认为是全球范围内对人类健康的严重威胁。OS 的发病率常见于长管状骨的干骺端，但在脊柱、骨盆和骶骨区域较为罕见；此外，大多数 OS 患者仅表现为单个病灶。OS 呈双峰分布模式，即其发病率在生命的第二个十年和成年晚期达到高峰。我们查阅了历史和当前的文献，对 OS 进行了简明的综述。在本综述中，我们讨论了 OS 的类型、临床诊断以及现代和未来的治疗方法。本文的目的是激发新的思路，开发更有效的治疗选择。
