Yang Jie, Yang Yin-Jun, Sun Xin-Guang, Zhang Jie, Zhao Yang, Wang Bei, Ding Qian-Zhi, Guo Bao-Lin, Ma Bai-Ping
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Beijing Institute of Radiation Medicine, No. 27, Taiping Road, Beijing 100850, China.
Molecules. 2017 Aug 2;22(8):1283. doi: 10.3390/molecules22081283.
Three new sesquiterpene glycosides, possessing a rare aglycone with a sulfonyl between C-1 and C-15 positions, named 3-(3'-7',8'-dihydroxy-4',8'-dimethyl-3'-nonenyl)-2,5-dihydro-1,1-dioxo-thiophen 7'--β-d-glucopyranosyl-(1→4)--β-d-glucopyranosyl-(1→4)--β-d-glucopyranoside (), 3-(3'-7',8'-dihydroxy-4',8'-dimethyl-3'-nonenyl)-2,5-dihydro-1,1-dioxo-thiophen 7'--β-d-glucopyranosyl-(1→4)--β-d-glucopyranoside (), and 3-(3'-7',8'-dihydroxy-4',8'-dimethyl-3'-nonenyl)-2,5-dihydro-1,1-dioxo-thiophen 7'--β-d-glucopyranosyl-6'--acetyl-(1→4)--β-d-glucopyranosyl-(1→4)--β-d-glucopyranoside (), respectively, were isolated from the rhizomes of . Their structures were established on the basis of spectroscopic data, including HR-ESI-MS, IR, 1D and 2D NMR. The cytotoxic properties of the three compounds were investigated using human hepatic L02 cells.
从[植物名称]的根茎中分离出三种新的倍半萜糖苷，它们具有一种罕见的苷元，在C-1和C-15位之间有一个磺酰基，分别命名为3-(3'-7',8'-二羟基-4',8'-二甲基-3'-壬烯基)-2,5-二氢-1,1-二氧代噻吩7'-β-D-吡喃葡萄糖基-(1→4)-β-D-吡喃葡萄糖基-(1→4)-β-D-吡喃葡萄糖苷（）、3-(3'-7',8'-二羟基-4',8'-二甲基-3'-壬烯基)-2,5-二氢-1,1-二氧代噻吩7'-β-D-吡喃葡萄糖基-(1→4)-β-D-吡喃葡萄糖苷（）和3-(3'-7',8'-二羟基-4',8'-二甲基-3'-壬烯基)-2,5-二氢-1,1-二氧代噻吩7'-β-D-吡喃葡萄糖基-6'-乙酰基-(1→4)-β-D-吡喃葡萄糖基-(1→4)-β-D-吡喃葡萄糖苷（）。它们的结构是根据光谱数据确定的，包括高分辨电喷雾电离质谱（HR-ESI-MS）、红外光谱（IR）、一维和二维核磁共振谱（1D和2D NMR）。使用人肝L02细胞研究了这三种化合物的细胞毒性。
