直立延龄草地下部分的甾体糖苷及其细胞毒性活性。
Steroidal glycosides from the underground parts of Trillium erectum and their cytotoxic activity.
作者信息
Yokosuka Akihito, Mimaki Yoshihiro
机构信息
Tokyo University of Pharmacy and Life Sciences, School of Pharmacy, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
出版信息
Phytochemistry. 2008 Nov;69(15):2724-30. doi: 10.1016/j.phytochem.2008.08.004. Epub 2008 Sep 25.
Six steroidal glycosides, along with 14 known compounds, were isolated from the underground parts of Trillium erectum L. (Liliaceae). The structures of 1-6 were determined on the basis of extensive spectroscopic analysis, including two-dimensional (2D) NMR data, and a few chemical transformations. The isolated compounds were evaluated for their cytotoxic activity against HL-60 human promyelocytic leukemia cells.
从直立延龄草（百合科）的地下部分分离出六种甾体苷以及14种已知化合物。基于广泛的光谱分析，包括二维（2D）核磁共振数据和一些化学转化，确定了化合物1-6的结构。对分离出的化合物进行了针对HL-60人早幼粒细胞白血病细胞的细胞毒性活性评估。
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