Mchedlishvili M A, Churadze T A, Zhorzholiani L D
Biull Eksp Biol Med. 1986 Oct;102(10):410-2.
Experimental investigations on guinea-pigs were carried out to study the role of tyrosine in the prevention of anaphylaxis. It should be noted that the intensity of clinical manifestations of anaphylactic shock was reduced in 5 out of 24 L-tyrosine fed guinea-pigs (20.83%), while in 9 animals (37.5%) anaphylactic shock did not develop. 100% death of control animals was registered. The effect of tyrosine was absent only in 10 guinea-pigs. Positive effect of tyrosine was followed by tyrosine-aminotransferase activation with a tendency towards the decrease in tyrosine plasma level and the rise in cortisol blood level. It is suggested that tyrosine increases glucocorticoid secretion of the adrenal cortex: Glucocorticoids in their turn, enhance tyrosine-aminotransferase activity in the animal liver.
对豚鼠进行了实验研究，以探讨酪氨酸在预防过敏反应中的作用。应当指出，在24只喂食L-酪氨酸的豚鼠中，有5只（20.83%）过敏休克临床表现的强度有所降低，而9只动物（37.5%）未发生过敏休克。对照动物的死亡率为100%。仅10只豚鼠未出现酪氨酸的作用。酪氨酸产生积极作用后，酪氨酸转氨酶被激活，同时血浆酪氨酸水平有降低趋势，血液皮质醇水平升高。提示酪氨酸可增加肾上腺皮质糖皮质激素的分泌：而糖皮质激素反过来又增强动物肝脏中酪氨酸转氨酶的活性。
