*Clinical Director, Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY. †Resident, Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY. ‡Associate Professor, Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia. §Assistant Professor, Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh, Saudi Arabia. ¶Assistant Professor, Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia. ‖Resident, Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY.
Implant Dent. 2017 Oct;26(5):770-777. doi: 10.1097/ID.0000000000000634.
The aim of this systematic review and meta-analysis was to evaluate the role of osteogenic coatings (placement of a thin film of organic and inorganic osteoinductive and osteoproliferative materials) on implant surfaces in augmenting bone-to-implant contact (BIC) in osteoporotic bone.
To answer the focused question "Do osteogenic coatings on implant surfaces increase BIC in osteoporotic bone?" PubMed/MEDLINE, EMBASE, ISI Web of Knowledge, Scopus, and Google-Scholar databases were searched till June 2017 using different combinations of the following key words: bone-to-implant contact, coating, implant surface, osseointegration, and osteoporosis. Letters to the Editor, review articles, case-reports/case-series, and commentaries were excluded.
Six animal studies were included, in which osteoporosis was induced by bilateral ovariectomy. In all studies, implant surface roughness was increased by various osteogenic surface coatings including alumina, hydroxyapatite, calcium phosphate, and zoledronic acid. Five studies showed that bone volume and BIC are significantly higher around implants with coated surfaces than noncoated implants. In 1 study, there was no difference in BIC around coated and noncoated implants.
Although experimental studies have shown that osteogenic coatings are effective in enhancing BIC, their clinical relevance requires further investigations.
本系统评价和荟萃分析旨在评估在骨质疏松骨中，在种植体表面使用成骨涂层（放置一层薄的有机和无机成骨和促骨生成材料）来增强骨与种植体接触（BIC）的作用。
为了回答“在骨质疏松骨中，种植体表面的成骨涂层是否会增加 BIC？”这一聚焦问题，我们使用了以下关键词的不同组合，在 2017 年 6 月之前，对 PubMed/MEDLINE、EMBASE、ISI Web of Knowledge、Scopus 和 Google-Scholar 数据库进行了搜索：骨与种植体接触、涂层、种植体表面、骨整合和骨质疏松。排除了给编辑的信、综述文章、病例报告/病例系列和评论。
共纳入 6 项动物研究，这些研究通过双侧卵巢切除术诱导骨质疏松。在所有研究中，通过各种成骨表面涂层（包括氧化铝、羟基磷灰石、磷酸钙和唑来膦酸）增加了种植体表面的粗糙度。五项研究表明，涂层表面的种植体周围的骨体积和 BIC 明显高于非涂层种植体。在一项研究中，涂层和非涂层种植体周围的 BIC 没有差异。
尽管实验研究表明成骨涂层可有效增强 BIC，但它们的临床相关性需要进一步研究。
