• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

骨缺损愈合中生物材料的综述、现存不足及骨组织工程的未来机遇：尚未解决的挑战

A review of biomaterials in bone defect healing, remaining shortcomings and future opportunities for bone tissue engineering: The unsolved challenge.

作者信息

Winkler T, Sass F A, Duda G N, Schmidt-Bleek K

机构信息

Julius Wolff Institute, Charité - Universitätsmedizin Berlin and Berlin-Brandenburg Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

出版信息

Bone Joint Res. 2018 May 5;7(3):232-243. doi: 10.1302/2046-3758.73.BJR-2017-0270.R1. eCollection 2018 Mar.

DOI:10.1302/2046-3758.73.BJR-2017-0270.R1
PMID:29922441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5987690/
Abstract

Despite its intrinsic ability to regenerate form and function after injury, bone tissue can be challenged by a multitude of pathological conditions. While innovative approaches have helped to unravel the cascades of bone healing, this knowledge has so far not improved the clinical outcomes of bone defect treatment. Recent findings have allowed us to gain in-depth knowledge about the physiological conditions and biological principles of bone regeneration. Now it is time to transfer the lessons learned from bone healing to the challenging scenarios in defects and employ innovative technologies to enable biomaterial-based strategies for bone defect healing. This review aims to provide an overview on endogenous cascades of bone material formation and how these are transferred to new perspectives in biomaterial-driven approaches in bone regeneration. Cite this article: T. Winkler, F. A. Sass, G. N. Duda, K. Schmidt-Bleek. A review of biomaterials in bone defect healing, remaining shortcomings and future opportunities for bone tissue engineering: The unsolved challenge. 2018;7:232-243. DOI: 10.1302/2046-3758.73.BJR-2017-0270.R1.

摘要

尽管骨组织在损伤后具有自我修复形态和功能的内在能力，但它仍可能受到多种病理状况的挑战。虽然创新方法有助于揭示骨愈合的一系列过程，但迄今为止，这些知识并未改善骨缺损治疗的临床效果。最近的研究结果使我们能够深入了解骨再生的生理条件和生物学原理。现在是时候将从骨愈合中学到的经验应用于缺损修复这一具有挑战性的场景中，并采用创新技术来实现基于生物材料的骨缺损愈合策略了。本综述旨在概述骨材料形成的内源性过程，以及这些过程如何在生物材料驱动的骨再生方法中转化为新的视角。引用本文：T. 温克勒，F. A. 萨斯，G. N. 杜达，K. 施密特 - 布勒克。骨缺损愈合中的生物材料综述、现存不足及骨组织工程的未来机遇：未解决的挑战。2018年；7卷：232 - 243页。DOI: 10.1302/2046 - 3758.73.BJR - 2017 - 0270.R1 。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e7d/5987690/cfec56b02422/bonejointres-07-232-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e7d/5987690/3737308aa968/bonejointres-07-232-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e7d/5987690/ac1531119215/bonejointres-07-232-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e7d/5987690/3485c59ad7e6/bonejointres-07-232-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e7d/5987690/a02ba9f5a101/bonejointres-07-232-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e7d/5987690/4c3b7c3fd919/bonejointres-07-232-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e7d/5987690/f6139861094c/bonejointres-07-232-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e7d/5987690/cfec56b02422/bonejointres-07-232-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e7d/5987690/3737308aa968/bonejointres-07-232-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e7d/5987690/ac1531119215/bonejointres-07-232-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e7d/5987690/3485c59ad7e6/bonejointres-07-232-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e7d/5987690/a02ba9f5a101/bonejointres-07-232-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e7d/5987690/4c3b7c3fd919/bonejointres-07-232-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e7d/5987690/f6139861094c/bonejointres-07-232-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e7d/5987690/cfec56b02422/bonejointres-07-232-g007.jpg

相似文献

1
A review of biomaterials in bone defect healing, remaining shortcomings and future opportunities for bone tissue engineering: The unsolved challenge.骨缺损愈合中生物材料的综述、现存不足及骨组织工程的未来机遇：尚未解决的挑战
Bone Joint Res. 2018 May 5;7(3):232-243. doi: 10.1302/2046-3758.73.BJR-2017-0270.R1. eCollection 2018 Mar.
2
Improved cartilage regeneration by implantation of acellular biomaterials after bone marrow stimulation: a systematic review and meta-analysis of animal studies.骨髓刺激后植入脱细胞生物材料改善软骨再生：动物研究的系统评价和荟萃分析
PeerJ. 2016 Sep 8;4:e2243. doi: 10.7717/peerj.2243. eCollection 2016.
3
Biomaterials based strategies for skeletal muscle tissue engineering: existing technologies and future trends.基于生物材料的骨骼肌组织工程策略：现有技术和未来趋势。
Biomaterials. 2015;53:502-21. doi: 10.1016/j.biomaterials.2015.02.110. Epub 2015 Mar 21.
4
Biomaterial-mediated strategies targeting vascularization for bone repair.针对骨修复血管化的生物材料介导策略。
Drug Deliv Transl Res. 2016 Apr;6(2):77-95. doi: 10.1007/s13346-015-0236-0.
5
Three-dimensional (3D) printed scaffold and material selection for bone repair.三维（3D）打印支架和用于骨修复的材料选择。
Acta Biomater. 2019 Jan 15;84:16-33. doi: 10.1016/j.actbio.2018.11.039. Epub 2018 Nov 24.
6
Engineering mechanical gradients in next generation biomaterials - Lessons learned from medical textile design.下一代生物材料中的工程机械梯度——从医用纺织品设计中获得的经验教训。
Acta Biomater. 2017 Jul 1;56:14-24. doi: 10.1016/j.actbio.2017.03.004. Epub 2017 Mar 6.
7
Healing of extraction sockets and surgically produced - augmented and non-augmented - defects in the alveolar ridge. An experimental study in the dog.拔牙创口以及牙槽嵴上手术制造的（包括增量和未增量的）缺损的愈合：一项在犬类动物上的实验研究
J Clin Periodontol. 2005 May;32(5):435-40. doi: 10.1111/j.1600-051X.2005.00692.x.
8
Current state of fabrication technologies and materials for bone tissue engineering.骨组织工程的制造技术和材料的现状。
Acta Biomater. 2018 Oct 15;80:1-30. doi: 10.1016/j.actbio.2018.09.031. Epub 2018 Sep 22.
9
Tissue engineering strategies for the treatment of tendon injuries: a systematic review and meta-analysis of animal models.治疗肌腱损伤的组织工程策略：动物模型的系统评价与荟萃分析
Bone Joint Res. 2018 May 5;7(4):318-324. doi: 10.1302/2046-3758.74.BJR-2017-0326. eCollection 2018 Apr.
10
Guided tissue engineering for healing of cancellous and cortical bone using a combination of biomaterial based scaffolding and local bone active molecule delivery.引导组织工程学在使用基于生物材料的支架和局部骨活性分子递送的组合治疗松质骨和皮质骨中的应用。
Biomaterials. 2019 Jan;188:38-49. doi: 10.1016/j.biomaterials.2018.10.004. Epub 2018 Oct 4.

引用本文的文献

1
Is it safe to use bone tissue for transplants stored for more than five years in a human tissue bank?在人体组织库中储存超过五年的骨组织用于移植是否安全？
Cell Tissue Bank. 2025 Sep 1;26(3):38. doi: 10.1007/s10561-025-10185-0.
2
Single-cell profiling reveals periosteal signatures of impaired periosteal cells proliferation in a drill-hole model of type 2 diabetes.单细胞分析揭示了2型糖尿病钻孔模型中骨膜细胞增殖受损的骨膜特征。
Cell Commun Signal. 2025 Aug 12;23(1):371. doi: 10.1186/s12964-025-02349-y.
3
Nucleic acid aptamers in orthopedic diseases: promising therapeutic agents for bone disorders.

本文引用的文献

1
A Call for Standardization in Platelet-Rich Plasma Preparation Protocols and Composition Reporting: A Systematic Review of the Clinical Orthopaedic Literature.呼吁标准化富血小板血浆制备方案和组成报告：临床矫形文献的系统评价。
J Bone Joint Surg Am. 2017 Oct 18;99(20):1769-1779. doi: 10.2106/JBJS.16.01374.
2
A Systematic Review of Clinical Studies Investigating Mesenchymal Stem Cells for Fracture Non-Union and Bone Defects.系统评价临床研究调查间充质干细胞治疗骨折不愈合和骨缺损。
Curr Stem Cell Res Ther. 2018;13(4):284-291. doi: 10.2174/1574888X12666170915121137.
3
Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications.
骨科疾病中的核酸适配体：治疗骨病的潜在治疗剂。
Bone Res. 2025 Jul 24;13(1):71. doi: 10.1038/s41413-025-00447-8.
4
Enhancing Bone Repair with β-TCP-Based Composite Scaffolds: A Review of Design Strategies and Biological Mechanisms.基于β-磷酸三钙的复合支架增强骨修复：设计策略与生物学机制综述
Orthop Res Rev. 2025 Jul 14;17:313-340. doi: 10.2147/ORR.S525959. eCollection 2025.
5
Additive Manufacturing, Thermoplastics, CAD Technology, and Reverse Engineering in Orthopedics and Neurosurgery-Applications to Preventions and Treatment of Infections.增材制造、热塑性塑料、CAD技术以及逆向工程在骨科和神经外科中的应用——用于感染的预防和治疗
Antibiotics (Basel). 2025 May 31;14(6):565. doi: 10.3390/antibiotics14060565.
6
Multi-omics insights into bone tissue injury and healing: bridging orthopedic trauma and regenerative medicine.骨组织损伤与愈合的多组学见解：连接骨科创伤与再生医学
Burns Trauma. 2025 May 28;13:tkaf019. doi: 10.1093/burnst/tkaf019. eCollection 2025.
7
Treatment of large bone defects in load-bearing bone: traditional and novel bone grafts.承重骨大骨缺损的治疗：传统与新型骨移植材料
J Zhejiang Univ Sci B. 2025 Apr 30;26(5):421-447. doi: 10.1631/jzus.B2300669.
8
Bone Regeneration: A Review of Current Treatment Strategies.骨再生：当前治疗策略综述
J Clin Med. 2025 Mar 8;14(6):1838. doi: 10.3390/jcm14061838.
9
The Role of Crosslinking Agents in the Development of Collagen-Hydroxyapatite Composite Materials for Bone Tissue Engineering.交联剂在用于骨组织工程的胶原-羟基磷灰石复合材料开发中的作用。
Materials (Basel). 2025 Feb 24;18(5):998. doi: 10.3390/ma18050998.
10
Synthetic Nanopillars for Stimulating Osteoblast Activity and Osteointegration in Bone-Related Disorders.用于刺激成骨细胞活性和骨相关疾病中骨整合的合成纳米柱
Int J Nanomedicine. 2025 Feb 19;20:2205-2223. doi: 10.2147/IJN.S501963. eCollection 2025.
磷酸钙生物陶瓷：历史、结构、性能、涂层技术及生物医学应用综述
Materials (Basel). 2017 Mar 24;10(4):334. doi: 10.3390/ma10040334.
4
Role of Osteogenic Coatings on Implant Surfaces in Promoting Bone-To-Implant Contact in Experimental Osteoporosis: A Systematic Review and Meta-Analysis.种植体表面成骨涂层在促进实验性骨质疏松症中骨与种植体接触的作用：系统评价和荟萃分析。
Implant Dent. 2017 Oct;26(5):770-777. doi: 10.1097/ID.0000000000000634.
5
Acidity-Triggered Ligand-Presenting Nanoparticles To Overcome Sequential Drug Delivery Barriers to Tumors.酸度触发配体递呈纳米颗粒以克服肿瘤的序贯药物递送障碍。
Nano Lett. 2017 Sep 13;17(9):5429-5436. doi: 10.1021/acs.nanolett.7b02031. Epub 2017 Aug 1.
6
[Autologous fibula transplantation for reconstruction of bone defects].[自体腓骨移植用于骨缺损重建]
Orthopade. 2017 Aug;46(8):648-655. doi: 10.1007/s00132-017-3442-2.
7
NIR and UV-responsive degradable hyaluronic acid nanogels for CD44-targeted and remotely triggered intracellular doxorubicin delivery.近红外和紫外响应可降解透明质酸纳米凝胶用于 CD44 靶向和远程触发的细胞内阿霉素递送。
Colloids Surf B Biointerfaces. 2017 Oct 1;158:547-555. doi: 10.1016/j.colsurfb.2017.07.041. Epub 2017 Jul 18.
8
Bioinspired Composite Matrix Containing Hydroxyapatite-Silica Core-Shell Nanorods for Bone Tissue Engineering.仿生复合基质，内含羟基磷灰石-二氧化硅核壳纳米棒，用于骨组织工程。
ACS Appl Mater Interfaces. 2017 Aug 16;9(32):26707-26718. doi: 10.1021/acsami.7b07131. Epub 2017 Aug 2.
9
In-situ tissue regeneration through SDF-1α driven cell recruitment and stiffness-mediated bone regeneration in a critical-sized segmental femoral defect.通过SDF-1α驱动的细胞募集和刚度介导的骨再生实现原位组织再生，用于治疗临界尺寸的股骨节段性缺损。
Acta Biomater. 2017 Sep 15;60:50-63. doi: 10.1016/j.actbio.2017.07.032. Epub 2017 Jul 21.
10
Inflammation-responsive self-regulated drug release from ultrathin hydrogel coating.超薄水凝胶涂层中炎症响应的自调节药物释放。
Colloids Surf B Biointerfaces. 2017 Oct 1;158:518-526. doi: 10.1016/j.colsurfb.2017.07.035. Epub 2017 Jul 18.