Sports and Exercise Physiology Laboratory, Department of Physiology, University of Calcutta, University Colleges of Science and Technology, Kolkata, India.
J Strength Cond Res. 2018 Apr;32(4):1045-1052. doi: 10.1519/JSC.0000000000002167.
Pal, S, Chaki, B, Chattopadhyay, S, and Bandyopadhyay, A. High-intensity exercise induced oxidative stress and skeletal muscle damage in post-pubertal boys and girls: a comparative study. J Strength Cond Res 32(4): 1045-1052, 2018-The purpose of this study was to examine the sex variation in high-intensity exercise induced oxidative stress and muscle damage among 44 sedentary postpubertal boys and girls through estimation of postexercise release pattern of muscle damage markers like creatine kinase, lactate dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and oxidative stress markers like extent of lipid peroxidation (thiobarbituric acid-reactive substances) and catalase activity. Muscle damage markers like creatine kinase, LDH, ALT, and AST were measured before, immediately after, and 24 and 48 hours after high-intensity incremental treadmill running. Oxidative stress markers like thiobarbituric acid-reactive substances and catalase activity were estimated before and immediately after the exercise. Lipid peroxidation and serum catalase activity increased significantly in both groups after exercise (p < 0.001) with postexercise values and percentage increase significantly higher in postpubertal boys as compared to girls (p < 0.001). Creatine kinase and LDH activity also increased significantly above pre-exercise level at 24 and 48 hours after exercise in both the sexes, (p < 0.001) with values significantly higher for boys than the girls (p < 0.001). Although ALT and AST increased significantly in both the groups after exercise, the pattern of postexercise release of these markers were found to be similar in both the groups. Accordingly, it has been concluded from the present investigation that high-intensity exercise induces significant oxidative stress and increases indices of skeletal muscle damage in both postpubertal girls and boys. However, postpubertal girls are relatively better protected from oxidative stress and muscle damage as compared to the boys of similar age and physical activity level. It is further evident that sex difference may not be apparent for all the biomarkers of muscle damage in this age group.
帕尔、查基、恰托帕迪雅、班迪奥帕迪雅。高强度运动诱导青春期后男孩和女孩的氧化应激和骨骼肌损伤：一项比较研究。《力量与调节研究杂志》32（4）：1045-1052，2018 年-本研究旨在通过估计运动后肌肉损伤标志物（如肌酸激酶、乳酸脱氢酶（LDH）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）的释放模式，以及氧化应激标志物（如丙二醛含量和过氧化氢酶活性），来研究高强度运动引起的氧化应激和肌肉损伤在青春期后男孩和女孩中的性别差异。在高强度递增跑步机跑步前、后即刻以及 24 和 48 小时测量肌肉损伤标志物，如肌酸激酶、LDH、ALT 和 AST。在运动前后测量氧化应激标志物，如丙二醛和过氧化氢酶活性。运动后两组的丙二醛和血清过氧化氢酶活性均显著升高（p<0.001），运动后值和增加百分比在青春期后男孩中显著高于女孩（p<0.001）。在 24 和 48 小时运动后，两组的肌酸激酶和 LDH 活性也显著高于运动前水平（p<0.001），且男孩的值显著高于女孩（p<0.001）。虽然运动后两组的 ALT 和 AST 均显著升高，但发现这些标志物的运动后释放模式在两组中相似。因此，从本研究中可以得出结论，高强度运动可导致青春期后女孩和男孩产生显著的氧化应激和增加骨骼肌损伤指标。然而，与年龄和运动水平相似的男孩相比，青春期后女孩受到氧化应激和肌肉损伤的相对保护较好。此外，在这个年龄组中，性别差异对于所有肌肉损伤的生物标志物可能并不明显。
