Wang Hong, van Spyk Elyse, Liu Qiang, Geyfman Mikhail, Salmans Michael L, Kumar Vivek, Ihler Alexander, Li Ning, Takahashi Joseph S, Andersen Bogi
State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Cell Biology and Genetics, School of Preclinical Medicine, Guangxi Medical University, Nanning 530021, China.
Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Cell Rep. 2017 Aug 1;20(5):1061-1072. doi: 10.1016/j.celrep.2017.07.022.
The epidermis is a highly regenerative barrier protecting organisms from environmental insults, including UV radiation, the main cause of skin cancer and skin aging. Here, we show that time-restricted feeding (RF) shifts the phase and alters the amplitude of the skin circadian clock and affects the expression of approximately 10% of the skin transcriptome. Furthermore, a large number of skin-expressed genes are acutely regulated by food intake. Although the circadian clock is required for daily rhythms in DNA synthesis in epidermal progenitor cells, RF-induced shifts in clock phase do not alter the phase of DNA synthesis. However, RF alters both diurnal sensitivity to UVB-induced DNA damage and expression of the key DNA repair gene, Xpa. Together, our findings indicate regulation of skin function by time of feeding and emphasize a link between circadian rhythm, food intake, and skin health.
表皮是一种具有高度再生能力的屏障，可保护生物体免受环境侵害，包括紫外线辐射，而紫外线辐射是皮肤癌和皮肤衰老的主要原因。在此，我们表明限时进食（RF）会改变皮肤生物钟的相位并改变其振幅，并影响约10%的皮肤转录组的表达。此外，大量在皮肤中表达的基因会受到食物摄入的急性调控。虽然生物钟对于表皮祖细胞中DNA合成的日常节律是必需的，但RF诱导的生物钟相位变化并不会改变DNA合成的相位。然而，RF会改变对UVB诱导的DNA损伤的昼夜敏感性以及关键DNA修复基因Xpa的表达。总之，我们的研究结果表明进食时间对皮肤功能有调控作用，并强调了昼夜节律、食物摄入与皮肤健康之间的联系。
