Perry Christina J, Lawrence Andrew J
Behavioural Neuroscience Division, The Florey Institute of Neuroscience and Mental Health, ParkvilleVIC, Australia.
Florey Department of Neuroscience and Mental Health, University of Melbourne, MelbourneVIC, Australia.
Front Pharmacol. 2017 Jul 18;8:478. doi: 10.3389/fphar.2017.00478. eCollection 2017.
In the past century there have been incredible advances in the field of medical research, but what hinders translation of this knowledge into effective treatment for human disease? There is an increasing focus on the failure of many research breakthroughs to be translated through the clinical trial process and into medical practice. In this mini review, we will consider some of the reasons that findings in basic medical research fail to become translated through clinical trials and into basic medical practices. We focus in particular on the way that human disease is modeled, the understanding we have of how our targets behave , and also some of the issues surrounding reproducibility of basic research findings. We will also look at some of the ways that have been proposed for overcoming these issues. It appears that there needs to be a cultural shift in the way we fund, publish and recognize quality control in scientific research. Although this is a daunting proposition, we hope that with increasing awareness and focus on research translation and the hurdles that impede it, the field of medical research will continue to inform and improve medical practice across the world.
在过去的一个世纪里，医学研究领域取得了令人难以置信的进展，但是什么阻碍了将这些知识转化为人类疾病的有效治疗方法呢？越来越多的人关注到许多研究突破未能通过临床试验过程转化为医学实践。在这篇小型综述中，我们将探讨基础医学研究结果未能通过临床试验转化为基础医学实践的一些原因。我们特别关注人类疾病建模的方式、我们对靶点行为的理解，以及基础研究结果可重复性的一些相关问题。我们还将探讨为克服这些问题而提出的一些方法。看来，在我们资助、发表和认可科学研究质量控制的方式上需要有文化转变。尽管这是一个艰巨的提议，但我们希望随着对研究转化以及阻碍它的障碍的认识和关注不断增加，医学研究领域将继续为世界各地的医学实践提供信息并加以改进。
