Department of Rehabilitation Medicine, Seonam Hospital, Ewha Womans University Medical Center, Seoul, Republic of Korea.
Department of Rehabilitation Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
Neural Plast. 2017;2017:1372946. doi: 10.1155/2017/1372946. Epub 2017 Jul 9.
Repetitive mild traumatic brain injury (rmTBI) provokes behavioral and cognitive changes. But the study about electrophysiologic findings and managements of rmTBI is limited. In this study, we investigate the effects of anodal transcranial direct current stimulation (tDCS) on rmTBI. Thirty-one Sprague Dawley rats were divided into the following groups: sham, rmTBI, and rmTBI treated by tDCS. Animals received closed head mTBI three consecutive times a day. Anodal tDCS was applied to the left motor cortex. We evaluated the motor-evoked potential (MEP) and the somatosensory-evoked potential (SEP). T2-weighted magnetic resonance imaging was performed 12 days after rmTBI. After rmTBI, the latency of MEP was prolonged and the amplitude in the right hind limb was reduced in the rmTBI group. The latency of SEP was delayed and the amplitude was decreased after rmTBI in the rmTBI group. In the tDCS group, the amplitude in both hind limbs was increased after tDCS in comparison with the values before rmTBI. Anodal tDCS after rmTBI seems to be a useful tool for promoting transient motor recovery through increasing the synchronicity of cortical firing, and it induces early recovery of consciousness. It can contribute to management of concussion in humans if further study is performed.
重复性轻度创伤性脑损伤（rmTBI）可引发行为和认知改变。但是，关于 rmTBI 的电生理发现和治疗的研究有限。在这项研究中，我们研究了阳极经颅直流电刺激（tDCS）对 rmTBI 的影响。将 31 只 Sprague Dawley 大鼠分为以下几组：假手术组、rmTBI 组和 rmTBI 联合 tDCS 治疗组。动物每天接受连续 3 次闭合性头部 mTBI。阳极 tDCS 施加于左运动皮层。我们评估了运动诱发电位（MEP）和体感诱发电位（SEP）。在 rmTBI 后 12 天进行 T2 加权磁共振成像。在 rmTBI 后，rmTBI 组的 MEP 潜伏期延长，右侧后肢的振幅降低。rmTBI 组的 SEP 潜伏期延迟，振幅降低。在 tDCS 组中，与 rmTBI 前相比，tDCS 后双侧后肢的振幅均增加。rmTBI 后阳极 tDCS 似乎是一种通过增加皮质放电同步性来促进短暂运动恢复的有用工具，并且可以诱导意识的早期恢复。如果进一步研究，它可以为人类脑震荡的治疗做出贡献。
